Review Application of locally responsive design of biomaterials based on microenvironmental changes in myocardial infarction

作者全名："Wang, Yiren; Li, Junlin; Han, Hukui; Huang, Huihui; Du, Huan; Cheng, Lianying; Ma, Cui; Cai, Yongxiang; Li, Gang; Tao, Jianhong; Cheng, Panke"

作者地址："[Wang, Yiren; Li, Junlin; Han, Hukui; Huang, Huihui; Du, Huan; Cai, Yongxiang; Li, Gang; Tao, Jianhong; Cheng, Panke] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Inst Cardiovasc Dis, Sch Med, Chengdu 610072, Peoples R China; [Wang, Yiren; Li, Junlin; Han, Hukui; Huang, Huihui; Du, Huan; Cai, Yongxiang; Li, Gang; Tao, Jianhong; Cheng, Panke] Univ Elect Sci & Technologyof China, Sichuan Prov Peoples Hosp, Sch Med, Dept Cardiol, Chengdu 610072, Peoples R China; [Cheng, Lianying] Chongqing Med Univ, Affiliated Hosp 1, Dept Integrated Tradit Chinese & Western Med, Chongqing 400016, Peoples R China; [Ma, Cui] Army Med Univ, Dept Math, Chongqing 400038, Peoples R China; [Cheng, Panke] Sichuan Prov Peoples Hosp, Ultrasound Cardiac Electrophysiol & Biomech Key La, Chengdu 610072, Peoples R China"

通信作者："Cheng, PK (通讯作者)，Sichuan Prov Peoples Hosp, Ultrasound Cardiac Electrophysiol & Biomech Key La, Chengdu 610072, Peoples R China."

来源：ISCIENCE

ESI学科分类：　

WOS号：WOS:001156899200001

JCR分区：Q1

影响因子：4.6

年份：2023

卷号：26

期号：9

开始页：　

结束页：　

文献类型：Review

关键词：　

摘要："Morbidity and mortality caused by acute myocardial infarction (AMI) are on the rise, posing a grave threat to the health of the general population. Up to now, interventional, surgical, and pharmaceutical therapies have been the main treatment methods for AMI. Effective and timely reperfusion therapy decreases mortality, but it cannot stimulate myocardial cell regeneration or reverse ventricular remodeling. Cell therapy, gene therapy, immunotherapy, anti-inflammatory therapy, and several other techniques are utilized by researchers to improve patients' prognosis. In recent years, biomaterials for AMI therapy have become a hot spot in medical care. Biomaterials furnish a microenvironment conducive to cell growth and deliver therapeutic factors that stimulate cell regeneration and differentiation. Biomaterials adapt to the complex microenvironment and respond to changes in local physical and biochemical conditions. Therefore, environmental factors and material properties must be taken into account when designing biomaterials for the treatment of AMI. This article will review the factors that need to be fully considered in the design of biological materials."

基金机构："National Natural Science Foundation of China [32000967, 82000530]; Sichuan Provincial People's Hospital Foundation [2020QN01]; Sichuan Cadre Health Research Project [ZH2022-201]; Chengdu Key R&D Support Program Major Technology Application Demonstration Project [2021-YF09-00033-SN]; Natural Science Foundation of Sichuan Province [2022NSFSC0817, 2022NSFSC0811, 23NSFSC1540, 23NSFSC1541]; Sichuan Provincial Science and Technology Program [2023YFS0036]"

基金资助正文："This work was supported by National Natural Science Foundation of China (No. 32000967) , Sichuan Provincial People's Hospital Foundation (No. 2020QN01) , Sichuan Cadre Health Research Project (No. Chuanganyan ZH2022-201) , Chengdu Key R & D Support Program Major Technology Application Demonstration Project (No. 2021-YF09-00033-SN), Natural Science Foundation of Sichuan Province (No.2022NSFSC0817; No. 2022NSFSC0811; No. 23NSFSC1540; No. 23NSFSC1541), Sichuan Provincial Science and Technology Program(2023YFS0036) and National Natural Science Foundation of China (No. 82000530)"