Abnormal interlimb coordination of motor developmental delay during infant crawling based on kinematic synergy analysis

作者全名："Zhang, Li; Xu, Chong; Chen, Lin; Liu, Yuan; Xiao, Nong; Wu, Xiaoying; Chen, Yuxia; Hou, Wensheng"

作者地址："[Zhang, Li; Xu, Chong; Chen, Lin; Wu, Xiaoying] Chongqing Univ, Bioengn Coll, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China; [Zhang, Li; Xu, Chong; Chen, Lin; Wu, Xiaoying; Hou, Wensheng] Chongqing Engn Res Ctr Med Elect Technol, Chongqing 400044, Peoples R China; [Liu, Yuan; Xiao, Nong; Chen, Yuxia] Chongqing Med Univ, Childrens Hosp, Dept Rehabil Ctr, Chongqing 400014, Peoples R China"

通信作者："Wu, XY (通讯作者)，Chongqing Univ, Bioengn Coll, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China.; Wu, XY (通讯作者)，Chongqing Engn Res Ctr Med Elect Technol, Chongqing 400044, Peoples R China.; Chen, YX (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Rehabil Ctr, Chongqing 400014, Peoples R China."

来源：BIOMEDICAL ENGINEERING ONLINE

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001157693900001

JCR分区：Q3

影响因子：2.9

年份：2024

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Kinematic synergies; Interlimb coordination; Motor developmental delay; Infant crawling; Non-negative matrix factorization

摘要："BackgroundPrevious studies have reported that abnormal interlimb coordination is a typical characteristic of motor developmental delay (MDD) during human movement, which can be visually manifested as abnormal motor postures. Clinically, the scale assessments are usually used to evaluate interlimb coordination, but they rely heavily on the subjective judgements of therapists and lack quantitative analysis. In addition, although abnormal interlimb coordination of MDD have been studied, it is still unclear how this abnormality is manifested in physiology-related kinematic features.ObjectivesThis study aimed to evaluate how abnormal interlimb coordination of MDD during infant crawling was manifested in the stability of joints and limbs, activation levels of synergies and intrasubject consistency from the kinematic synergies of tangential velocities of joints perspective.MethodsTangential velocities of bilateral shoulder, elbow, wrist, hip, knee and ankle over time were computed from recorded three-dimensional joint trajectories in 40 infants with MDD [16 infants at risk of developmental delay, 11 infants at high risk of developmental delay, 13 infants with confirmed developmental delay (CDD group)] and 20 typically developing infants during hands-and-knees crawling. Kinematic synergies and corresponding activation coefficients were derived from those joint velocities using the non-negative matrix factorization algorithm. The variability accounted for yielded by those synergies and activation coefficients, and the synergy weightings in those synergies were used to measure the stability of joints and limbs. To quantify the activation levels of those synergies, the full width at half maximum and center of activity of activation coefficients were calculated. In addition, the intrasubject consistency was measured by the cosine similarity of those synergies and activation coefficients.ResultsInterlimb coordination patterns during infant crawling were the combinations of four types of single-limb movements, which represent the dominance of each of the four limbs. MDD mainly reduced the stability of joints and limbs, and induced the abnormal activation levels of those synergies. Meanwhile, MDD generally reduced the intrasubject consistency, especially in CDD group.ConclusionsThese features have the potential for quantitatively evaluating abnormal interlimb coordination in assisting the clinical diagnosis and motor rehabilitation of MDD."

基金机构：National Natural Science Foundation of China; Department of Rehabilitation Center

基金资助正文："We would like to thank the Department of Rehabilitation Center, Children's Hospital of Chongqing Medical University for recruiting infants and assisting with the data collection. We also thank all infants and their guardians participated in the experiments for their valuable time."