Fe-Mediated Self-Assembled Nanodrug for Tumor Microenvironment Activated Synergistic Ferroptosis-Based-Chemodynamic/Chemo Therapy and Magnetic Resonance Imaging

作者全名："Xu, Zhongsheng; Zhang, Liang; Gong, Mingfu; Sun, Tao; Zhou, Chunyu; Xiao, Shilin; Liu, Yun; Zhang, Dong"

作者地址："[Xu, Zhongsheng; Zhang, Liang; Gong, Mingfu; Sun, Tao; Zhou, Chunyu; Xiao, Shilin; Liu, Yun; Zhang, Dong] Army Med Univ, Xinqiao Hosp, Dept Radiol, Chongqing 400037, Peoples R China; [Xu, Zhongsheng; Liu, Yun] Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China"

通信作者："Gong, MF; Liu, Y; Zhang, D (通讯作者)，Army Med Univ, Xinqiao Hosp, Dept Radiol, Chongqing 400037, Peoples R China.; Liu, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China."

来源：ACS MATERIALS LETTERS

ESI学科分类：　

WOS号：WOS:001158181900001

JCR分区：Q1

影响因子：9.6

年份：2024

卷号：6

期号：2

开始页：656

结束页：665

文献类型：Article

关键词：　

摘要："Due to the low drug concentration, glutathione (GSH)-based oxidative stress regulating system in target tissues, and serious side effects, doxorubicin (DOX) usually shows a suboptimal efficacy in clinical practice. The synergistic combination of DOX-based chemotherapy with iron ion-based chemodynamic therapy (CDT), sensitization of cancer cells by GSH depletion, and responsive targeted delivery of DOX have been regarded as a potential efficient strategy to improve the efficacy. Herein, benefiting from the strong lipoic acid-Fe3+ coordination, we synthesized the DOX@Fe3+-LA (DOX@FL) nanodrug with a one-pot method based on the Fe3+-DOX chelation, disulfide open-ring polymerization and self-assembly behavior of lipoic acid. The nanodrug showed a spherical, uniform morphology and a high loading of DOX and Fe. Under the tumor microenvironment, the nanodrug could synchronously release DOX and Fe, and then induce center dot OH generation and intracellular GSH depletion efficiently, showing a multimodality synergistic therapeutic effect in vitro and in vivo. Additionally, the DOX@FL showed pH- and GSH-responsive MRI due to the paramagnetism of Fe3+, suggesting that DOX@FL NPs be a simple, efficient, and multifunctional nanoplatform for cancer targeting treatment and MRI."

基金机构："National Natural Science Foundation of China [82372030, 81903561]; Natural Science Foundation of Chongqing [cstc2020jcyj-msxmX1017, cstc2022ycjh-bgzxm0082, cstc2021jcyj-msxmX1093]; Talent project of Chongqing [CQYC202103075]; Miaopu Foundation of Army Medical University [2019R059]"

基金资助正文："This work was supported by National Natural Science Foundation of China (Nos. 82372030, 81903561), Natural Science Foundation of Chongqing (Nos. cstc2020jcyj-msxmX1017, cstc2022ycjh-bgzxm0082, cstc2021jcyj-msxmX1093), Talent project of Chongqing (No. CQYC202103075), and Miaopu Foundation of Army Medical University (No. 2019R059)."