Analysis of Dopamine Receptor D2 Gene Polymorphism and Correlation with Dyslipidemia in the Chinese Population

作者全名："Tan, Haibo; Wang, Zhixue; Zhang, Jiaxuan; Huang, Maohua; Chen, Jide; Li, Fengqi; Tang, Liangjun"

作者地址："[Tan, Haibo; Wang, Zhixue; Zhang, Jiaxuan; Huang, Maohua; Chen, Jide; Tang, Liangjun] Chongqing Med Univ, Bishan Hosp, Dept Med Lab, Chongqing, Peoples R China; [Li, Fengqi] Zhongxian Peoples Hosp Chongqing, Dept Med Lab, Chongqing, Peoples R China"

通信作者："Tang, LJ (通讯作者)，Chongqing Med Univ, Bishan Hosp, Dept Med Lab, Chongqing, Peoples R China."

来源：MOLECULAR SYNDROMOLOGY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001159263600001

JCR分区：Q4

影响因子：0.9

年份：2023

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期号：　

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文献类型：Article; Early Access

关键词：DRD2; C957T polymorphism; Dyslipidemia; Susceptibility; CT genotype

摘要："Objective: The study aimed to explore the genotype and allele distributions of dopamine D2-like receptor (DRD2) gene -141C and C957T polymorphisms in the Chinese Han population with dyslipidemia, as well as their association with serum lipid levels. Methods: One hundred fifty patients with dyslipidemia and 150 healthy people were recruited as the case and the control groups, respectively. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol levels were detected. The target sequence of DRD2 polymorphisms was amplified by polymerase chain reaction and genotyped via Sanger sequencing. Results: In DRD2 gene C957T (rs6277), three genotypes of CC, CT, and TT were detected with the frequencies of 92.67%, 6.67%, 0.67% in dyslipidemia cases, and 83.33%, 14.67%, 2.00% in the controls, respectively. The CT genotype and T allele frequencies were significantly low in the case group relative to the control group. After adjusting to other clinical indicators, the CT genotype of C957T polymorphism (hazard ratio = 0.401, 95% confidence interval = 0.181-0.890, p < 0.05) was still related to a significantly reduced risk of dyslipidemia. The C957T CT genotype carriers had the lowest values of serum TC, TG, LDL, and the highest values of serum HDL-C. Conclusion: DRD2 gene C957T polymorphism was an independent influencing factor associated with the susceptibility to dyslipidemia, and the CT genotype was associated with decreased odds of susceptibility to dyslipidemia. (c) 2023 S. Karger AG, Basel"

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