"Secondhand smoke, genetic susceptibility, and incident chronic kidney disease in never smokers: A prospective study of a selected population from the UK Biobank"

作者全名："Lan, Rui; Li, Xue; Chen, Xiangjun; Hu, Jinbo; Luo, Wenjin; Lv, Liangjing; Shen, Yan; Qin, Yao; Mao, Lina; Ye, Hanwen; Li, Qifu; Wang, Zhihong"

作者地址："[Lan, Rui; Li, Xue; Chen, Xiangjun; Hu, Jinbo; Luo, Wenjin; Lv, Liangjing; Shen, Yan; Qin, Yao; Mao, Lina; Ye, Hanwen; Li, Qifu; Wang, Zhihong] Chongqing Med Univ, Dept Endocrinol, Affiliated Hosp 1, 1 Youyi St, Chongqing 400016, Peoples R China"

通信作者："Wang, ZH (通讯作者)，Chongqing Med Univ, Dept Endocrinol, Affiliated Hosp 1, 1 Youyi St, Chongqing 400016, Peoples R China."

来源：TOBACCO INDUCED DISEASES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001160413400001

JCR分区：Q2

影响因子：2.2

年份：2023

卷号：21

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：secondhand smoke; genetic susceptibility; chronic kidney disease; UK Biobank

摘要："INTRODUCTION A large number of people around the world are exposed to the risks of passive smoking. This prospective study aimed to examine the association between secondhand smoke exposure, exposure time, and the incidence of chronic kidney disease (CKD) and determine whether this association was influenced by genetic susceptibility. METHODS The study included 214244 participants of the UK Biobank who were initially free of CKD. Cox proportional hazards model was used to estimate the associations between secondhand smoke exposure time and the risks of CKD in people who have never smoked. The genetic risk score for CKD was calculated by a weighted method. The likelihood ratio test comparing models was used to examine the cross-product term between secondhand smoke exposure and genetic susceptibility to CKD outcomes. RESULTS During a median of 11.9 years of follow-up, 6583 incidents of CKD were documented. Secondhand smoke exposure increased the risk of CKD (HR=1.09; 95% CI: 1.03-1.16, p<0.01), and a dose-response relationship between CKD prevalence and secondhand smoke exposure time was found (p for trend<0.01). Secondhand smoke exposure increases the risk of CKD even in people who never smoke and have a low genetic risk (HR=1.13; 95% CI: 1.02-1.26, p=0.02). There was no statistically significant interaction between secondhand smoke exposure and genetic susceptibility to CKD (p for interaction=0.80). CONCLUSIONS Secondhand smoke exposure is associated with higher risk of CKD, even in people with low genetic risk, and the relationship is dose dependent. These findings change the belief that people with low genetic susceptibility and without direct participation in smoking activities are not prone to CKD, emphasizing the need to avoid the harm of secondhand smoke in public places."

基金机构：First batch of key Disciplines on Public Health in Chongqing; International Diabetes Exchange and Practice Special Fund [Z-2017-26-1902-2]; Technological Innovation and Application Development Project of Chongqing [cstc2019jscx-msxmX0138]; Innovative Funded Project of Chongqing Innovation and Retention Program [cx2019032]; Young and Middle-aged Senior Medical Talents studio of Chongqing [ZQNYXGDRCGZS2021001]

基金资助正文：This work was supported by: The First batch of key Disciplines on Public Health in Chongqing; International Diabetes Exchange and Practice Special Fund [Z-2017-26-1902-2]; Technological Innovation and Application Development Project of Chongqing [cstc2019jscx-msxmX0138]; Innovative Funded Project of Chongqing Innovation and Retention Program [cx2019032]; and the Young and Middle-aged Senior Medical Talents studio of Chongqing [ZQNYXGDRCGZS2021001].