LncRNA WWTR1-AS1 upregulates Notch3 through miR-136 to increase cancer cell stemness in cervical squamous cell carcinoma

作者全名："Zhou, Xiaofeng; Li, Zhizun; Li, Moyu"

作者地址："[Zhou, Xiaofeng; Li, Zhizun; Li, Moyu] Chongqing Med Univ, Bishan Hosp, Dept Obstet & Gynecol, 9 Shuangxing Ave,Biquan St, Chongqing 402760, Peoples R China"

通信作者："Li, MY (通讯作者)，Chongqing Med Univ, Bishan Hosp, Dept Obstet & Gynecol, 9 Shuangxing Ave,Biquan St, Chongqing 402760, Peoples R China."

来源：BMC WOMENS HEALTH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001160601200003

JCR分区：Q2

影响因子：2.4

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：WWTR1-AS1; CSCC; miR-136; Notch3; Stemness

摘要："BackgroundThis Study investigated the role of WWTR1-AS1 in cervical squamous cell carcinoma (CSCC).ResultsWWTR1-AS1 expression was upregulated in CSCC tissues. WWTR1-AS1 was predicted to interact with miR-136, whereas correlation analysis revealed that there was no close correlation between WWTR1-AS1 and miR-136 across CSCC samples. Moreover, WWTR1-AS1 and miR-136 did not regulate the expression of each other. In addition, overexpression of WWTR1-AS1 increased the expression levels of Notch3, which could be targeted by miR-136. Cell stemness analysis indicated that the overexpression of WWTR1-AS1 and Notch3 increased CSCC cell stemness and the capacity of CSCC cell to grow as spheroids. Overexpression of miR-136 decreased CSCC cell stemness and reversed the effects of overexpression of WWTR1-AS1 on Notch3 in CSCC cells.ConclusionTherefore, WWTR1-AS1 may upregulate Notch3 through miR-136 to increase cancer cell stemness in CSCC."

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