Photomediated Hydro(deutero)acylation of Olefins by Decarboxylative Addition of α-Oxocarboxylic Acids

作者全名："Gao, Fan; Liao, Zhi-Yu; Ye, Yu-Hang; Yu, Qian-Hui; Yang, Cui; Luo, Qing-Yu; Du, Fei; Pan, Bin; Zhong, Wen-Wu; Liang, Wu"

作者地址："[Gao, Fan; Liao, Zhi-Yu; Ye, Yu-Hang; Yu, Qian-Hui; Yang, Cui; Luo, Qing-Yu; Du, Fei; Liang, Wu] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China; [Pan, Bin] Third Mil Med Univ, Coll Pharm, Chongqing 400038, Peoples R China; [Zhong, Wen-Wu] Chongqing Med & Pharmaceut Coll, Dept Pharm, Chongqing 401334, Peoples R China"

通信作者："Liang, W (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China."

来源：JOURNAL OF ORGANIC CHEMISTRY

ESI学科分类：CHEMISTRY

WOS号：WOS:001160854800001

JCR分区：Q1

影响因子：3.3

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：　

摘要："Acyl radicals have been generated from the decarboxylation of alpha-oxocarboxylic acids by using a readily accessible organic pyrimidopteridine photoredox catalyst under ultraviolet-A (UV-A) light irradiation. These reactive acyl radicals were smoothly added to olefins such as styrenes and diverse Michael acceptors, with the assistance of H2O/D2O as hydrogen donors, enabling easy access to a diverse range of ketones/beta-deuterio ketones. A wide range of alpha-oxocarboxylic acids are compatible with this reaction, which shows a reliable, atom-economical, and eco-friendly protocol. Furthermore, postsynthetic diversifications and applications are presented."

基金机构：Chongqing Medical University [KJQN202100453]; Chongqing Municipal Education Commission [R13009]; Chongqing Medical University Start-Up Fund [YXY2021XSZ03]; College of Pharmacy CQMU [cstc2021jcyj-msxmX0201]; Natural Science Foundation of Chongqing [172020320220090 W0072]; CQMU Program for Youth Innovation in Future Medicine

基金资助正文："Financial support from Chongqing Municipal Education Commission (KJQN202100453), the Chongqing Medical University Start-Up Fund (R13009), the College of Pharmacy CQMU Start Up Fund for Youth (YXY2021XSZ03), the Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0201), and the CQMU Program for Youth Innovation in Future Medicine (172020320220090 W0072) is gratefully acknowledged."