Associations of <i>IL6R</i> and <i>IL10</i> Gene Polymorphisms with Susceptibility to Ankylosing Spondylitis with or without Acute Anterior Uveitis

作者全名："Lin, Li; Li, Fuzhen; Fang, Haixin; Zhou, Pengyi; Shan, Jiankang; Xie, Kunpeng; Jin, Bo; Zhu, Haiyan; Jin, Xuemin; Du, Liping; Yang, Peizeng"

作者地址："[Lin, Li; Li, Fuzhen; Fang, Haixin; Zhou, Pengyi; Shan, Jiankang; Xie, Kunpeng; Jin, Bo; Zhu, Haiyan; Jin, Xuemin; Du, Liping] Zhengzhou Univ, Affiliated Hosp 1, Dept Ophthalmol, Zhengzhou, Henan, Peoples R China; [Fang, Haixin; Shan, Jiankang] Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China; [Yang, Peizeng] Chongqing Med Univ, Affiliated Hosp 1, Chongqing Key Lab Ophthalmol, Chongqing, Peoples R China; [Yang, Peizeng] Chongqing Eye Inst, Chongqing, Peoples R China; [Yang, Peizeng] Zhengzhou Univ, Affiliated Hosp 1, Dept Ophthalmol, Zhengzhou 450000, Henan, Peoples R China"

通信作者："Du, LP (通讯作者)，Zhengzhou Univ, Affiliated Hosp 1, Dept Ophthalmol, Zhengzhou, Henan, Peoples R China.; Yang, PZ (通讯作者)，Zhengzhou Univ, Affiliated Hosp 1, Dept Ophthalmol, Zhengzhou 450000, Henan, Peoples R China."

来源：OCULAR IMMUNOLOGY AND INFLAMMATION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001160960800001

JCR分区：Q2

影响因子：2.6

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Acute anterior uveitis; ankylosing spondylitis; genetic variation; IL10; IL6R

摘要："Background: This research aims to explore the associations between ten candidate single nucleotide polymorphisms (SNPs) on Interleukin-6 receptor (IL6R) and Interleukin-10 (IL10) genes and ankylosing spondylitis (AS) patients with or without acute anterior uveitis (AAU). Methods: This study involved a case-control approach that examined 354 cases with AS and AAU, 377 AS cases without AAU, and 918 healthy controls. Genotyping of ten SNPs of IL10 and IL6R genes was performed using iPLEX Gold genotyping method. The allele and genotype frequencies of cases and healthy individuals were contrasted using the chi-square test. The IL10 mRNA level in various IL10 genotypes was tested using real-time PCR. Results: Two loci associated with AS with AAU were identified: IL10//rs3790622 (OR = 0.664; 95%CI = 0.503-0.878; Pc = 0.038); IL10//rs3021094 (OR = 1.365; 95%CI = 1.110-1.679; Pc = 0.032). The other eight loci located on IL10 and IL6R did not show significant associations with the diseases. Additionally, as shown by functional experiments, there was no correlation between the mRNA expression of IL10 and various genotypes. Conclusion: Our study suggests that the IL10 gene contributes to the susceptibility of the Chinese population to AS with AAU."

基金机构："Natural Science Foundation of China [8230041447, 82171040]; Medical Science and Technology Project of Health Commission of Henan Province [YXKC2020026]; Key Scientific Research Projects of Henan Province Colleges and Universities [23A320067]; Major Program of Medical Scientific and Technological of Henan Province (XXX); Medical Scientific and Technological Project of Henan Province [SBGJ2020003031]; National Natural Science Foundation Project [82101108]"

基金资助正文："This work was supported by National Natural Science Foundation of China [8230041447 and 82171040], Medical Science and Technology Project of Health Commission of Henan Province [YXKC2020026], Key Scientific Research Projects of Henan Province Colleges and Universities [23A320067], Major Program of Medical Scientific and Technological of Henan Province (XXX), Medical Scientific and Technological Project of Henan Province [SBGJ2020003031] and National Natural Science Foundation Project [82101108]."