"Expression, Prognostic Value, and Immune Infiltration of MTHFD Family in Bladder Cancer"

作者全名："Zheng, Bai Shu; De Wang, Shun; Zhang, Jun Yong; Ge, Cheng Guo"

作者地址："[Zheng, Bai Shu; Zhang, Jun Yong; Ge, Cheng Guo] Chongqing Med Univ, Affiliated Hosp 2, Dept Urol, Chongqing 400010, Peoples R China; [De Wang, Shun] ChenJiaqiao Hosp ShaPingba Dist Chongqing City, Dept Urol, Chongqing 401331, Peoples R China"

通信作者："Ge, CG (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Urol, Chongqing 400010, Peoples R China."

来源：CURRENT CANCER DRUG TARGETS

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001161998400002

JCR分区：Q3

影响因子：2.3

年份：2024

卷号：24

期号：2

开始页：178

结束页：191

文献类型：Article

关键词：Bladder cancer; prognostic markers; MTHFD family; immune infiltration; bioinformatics analysis; prognostic marker

摘要："Background: The Methylenetetrahydrofolate Dehydrogenase (MTHFD) family plays an important role in the development and prognosis of a variety of tumors; however, the role of the MTHFD family in bladder cancer is unclear.Methods R software, cBioPortal, GeneMANIA, and online sites such as String-LinkedOmics were used for bioinformatics analysis.Results MTHFD1/1L/2 was significantly upregulated in bladder cancer tissues compared with normal tissues, high expression of the MTHFD family was strongly associated with poorer clinical grading and staging, and bladder cancer patients with upregulated expression of MTHFD1L/2 had a significantly worse prognosis. Gene function and PPI network analysis revealed that the MTHFD family and related genes play synergistic roles in the development of bladder cancer. 800 co-expressed genes related to the MTHFD family were used for functional enrichment analysis, and the results showed that many genes were associated with various oncogenic pathways such as cell cycle and DNA replication. More importantly, the MTHFD family was closely associated with multiple infiltrating immune lymphocytes, including Treg cells, and immune molecules such as TNFSF9, CD274, and PDCD1.Conclusion Our study shows that MTHFD family genes may be potential prognostic markers and therapeutic targets for patients with bladder cancer."

基金机构：Kuanren Talents Program of Chongqing Medical University [KY2019Y026]; National Natural Science Foundation of China [81803057]

基金资助正文：This research was funded by the Kuanren Talents Program of Chongqing Medical University (Grant no. KY2019Y026) and the National Natural Science Foundation of China (Grant no. 81803057).