Pathology-Guided Cell Membrane-Coated Polydopamine Nanoparticles for Efficient Multisynergistic Treatment of Periodontitis

作者全名："Pan, Shengyuan; Zhong, Wenjie; Lan, Yuyan; Yu, Simin; Yang, Lanxin; Yang, Fengze; Li, Jinda; Gao, Xiang; Song, Jinlin"

作者地址："[Pan, Shengyuan; Zhong, Wenjie; Lan, Yuyan; Yu, Simin; Yang, Lanxin; Yang, Fengze; Li, Jinda; Gao, Xiang; Song, Jinlin] Chongqing Med Univ, Coll Stomatol, Chongqing 401147, Peoples R China; [Pan, Shengyuan; Zhong, Wenjie; Lan, Yuyan; Yu, Simin; Yang, Lanxin; Yang, Fengze; Li, Jinda; Gao, Xiang; Song, Jinlin] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China; [Pan, Shengyuan; Zhong, Wenjie; Lan, Yuyan; Yu, Simin; Yang, Lanxin; Yang, Fengze; Li, Jinda; Gao, Xiang; Song, Jinlin] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China"

通信作者："Gao, X; Song, JL (通讯作者)，Chongqing Med Univ, Coll Stomatol, Chongqing 401147, Peoples R China.; Gao, X; Song, JL (通讯作者)，Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China.; Gao, X; Song, JL (通讯作者)，Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China."

来源：ADVANCED FUNCTIONAL MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001162367200001

JCR分区：Q1

影响因子：19

年份：2024

卷号：34

期号：23

开始页：　

结束页：　

文献类型：Article

关键词：bioinspired nanoparticles; cell membrane coating; drug delivery; multi-bioactivities; periodontitis

摘要："Nanodrug delivery systems (NDDSs) for the treatment of periodontitis remain a significant clinical challenge. The low biocompatibility, singular effect, and lack of disease specificity of conventional nanoparticles limit their biomedical application. Recent studies have highlighted the pivotal role of cell membrane-coated nanotechnology in anti-inflammatory strategies due to its improved biocompatibility and superior biointerface properties. Herein, combined with the pathological heterogeneity of periodontitis revealed by bioinformatics analysis, this study develops a novel cell membrane-coated nanoparticle composed of two elements: minocycline-loaded polydopamine nanoparticles (PM) and cRGD-modified cell membrane (RCM). The in vitro results indicate that PM@RCM rescues impaired human periodontal ligament stem cells through antioxidant, anti-ferroptosis, anti-inflammatory, and pro-osteogenic effects, and exhibits favorable antibacterial bioactivity. The in vivo studies further reveal that PM@RCM promotes periodontal tissue regeneration and remodeled periodontal homeostasis in periodontitis mice. Collectively, these findings highlight the unique pathological changes in periodontitis. Moreover, the novel NDDS developed in this study, which leverages the excellent natural properties of cell membrane-coated nanotechnology and the versatility of nanoparticle cores, provides a promising strategy for the clinical treatment of periodontitis. Nanodrug delivery systems for the treatment of periodontitis remain a significant clinical challenge. Herein, combined with the pathological heterogeneity of periodontitis revealed by bioinformatics analysis, this study develops a novel cell membrane-coated nanoparticle, which leverages the excellent natural properties of cell membrane-coated nanotechnology and the versatility of nanoparticle cores, provides a promising strategy for the clinical treatment of periodontitis. image"

基金机构：National Natural Science Foundation of China; National Key R&D of Program of China [2022YFC2504200]; Program for Youth Innovation in Future Medicine of Chongqing Medical University [W0055]; Chongqing Young and Middle-aged Medical High-end Talent Studio; [U22A20314]; [82071072]; [82071093]; [31700850]

基金资助正文："S.P. and S.Y. contributed equally to this work. This work was supported by National Natural Science Foundation of China (U22A20314, 82071072, 82071093, 31700850), National Key R&D of Program of China (Grant No. 2022YFC2504200), Program for Youth Innovation in Future Medicine of Chongqing Medical University (W0055), and Chongqing Young and Middle-aged Medical High-end Talent Studio."