Early blood pressure lowering therapy is associated with good functional outcome in patients with intracerebral hemorrhage

作者全名："Lv, Xinni; Liu, Xueyun; Hu, Zicheng; Deng, Lan; Li, Zuoqiao; Cheng, Jing; Pu, Mingjun; Li, Qi"

作者地址："[Lv, Xinni; Deng, Lan; Li, Zuoqiao; Pu, Mingjun; Li, Qi] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China; [Liu, Xueyun; Li, Qi] Anhui Med Univ, Affiliated Hosp 2, Dept Neurol, Hefei, Peoples R China; [Hu, Zicheng] Peoples Hosp Chongqing Hechuan PHHC, Dept Neurol, Chongqing, Peoples R China; [Cheng, Jing] Chongqing Med Univ, Affiliated Hosp 3, Dept Neurol & Neurosurg, Chongqing, Peoples R China"

通信作者："Li, Q (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China.; Li, Q (通讯作者)，Anhui Med Univ, Affiliated Hosp 2, Dept Neurol, Hefei, Peoples R China."

来源：BMC NEUROLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001162425500001

JCR分区：Q3

影响因子：2.2

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Intracerebral hemorrhage; Outcome; Blood Pressure; Treatment

摘要："BackgroundThe implementation of a care bundle might improve functional outcome for patients with intracerebral hemorrhage (ICH). However, the impact of anti-hypertensive treatment on ICH outcomes remains uncertain. Our objective is to examine whether early blood pressure (BP) lowering therapy within first 12 h is associated with good outcome in ICH patients.MethodsWe included acute ICH patients who had baseline computed tomography (CT) scans within 6 h after onset of symptoms between October 2013 and December 2021. Early BP reduction was defined as use of anti-hypertensive agents within 12 h after onset of symptom. The clinical characteristics were compared between patients who received early BP lowering therapy and those without. The associations between early BP lowering and good outcome and functional independence at 3 months were assessed by using multivariable logistic regression analyses.ResultsA total of 377 patients were finally included in this study for outcome analysis. Of those, 212 patients received early BP reduction within 12 h after ICH. A total of 251 (66.6%) patients had good outcome. After adjustment for age, admission systolic BP, admission GCS score, baseline hematoma volume, hematoma expansion, and presence of intraventricular hemorrhage, early BP lowering therapy was associated with functional independence (adjusted odd ratio:1.72, 95% confidence interval:1.03-2.87; P = 0.039) and good outcome (adjusted odd ratio: 2.02, 95% confidence interval:1.08-3.76; P = 0.027).ConclusionsIn ICH patients presenting within 6 h after symptom onset, early BP reduction within first 12 h is associated with good outcome and functional independence when compared to those who do not undergo such early intervention. Implementation of quality measures to ensure early BP reduction is crucial for management of ICH."

基金机构：National Natural Science Foundation of China [82071337]; Chongqing Innovation Support Program for Returned Overseas Chinese Scholars [cx2020002]; Chongqing Science Fund for Distinguished Young Scholars [cstc2021jcyj-jqX0029]; Research Fund of Anhui Institute of translational medicine [2022zhyx-C38]; First Affiliated Hospital of Chongqing Medical University PhD Innovation Program [CYYY-BSYJSCXXM-202314]

基金资助正文："This study was supported by the National Natural Science Foundation of China (Grant No. 82071337), the Chongqing Innovation Support Program for Returned Overseas Chinese Scholars (GrantNo. cx2020002), Chongqing Science Fund for Distinguished Young Scholars (Grant No.cstc2021jcyj-jqX0029), Research Fund of Anhui Institute of translational medicine (Grant No.2022zhyx-C38), and the First Affiliated Hospital of Chongqing Medical University PhD Innovation Program (Grant No. CYYY-BSYJSCXXM-202314)."