Correlation between metabolic syndrome and periurethral prostatic fibrosis: results of a prospective study

作者全名："Ren, Jingwen; Li, Yuanyuan; Zhang, Xueyuan; Xiong, Min; Zhang, Heng; An, Lingyue; Cao, Ying; Xia, Shujie; Luo, Guangheng; Tian, Ye"

作者地址："[Ren, Jingwen; Li, Yuanyuan; Xiong, Min; Zhang, Heng; An, Lingyue; Luo, Guangheng; Tian, Ye] Guizhou Prov Peoples Hosp, Dept Urol, Guiyang, Peoples R China; [Ren, Jingwen] Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing, Peoples R China; [Li, Yuanyuan; Cao, Ying; Luo, Guangheng; Tian, Ye] Guizhou Univ, Sch Med, Guiyang, Peoples R China; [Zhang, Xueyuan] Zunyi Med Univ, Zunyi, Peoples R China; [Xia, Shujie] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Urol, Shanghai, Peoples R China"

通信作者："Tian, Y (通讯作者)，Guizhou Prov Peoples Hosp, Dept Urol, Guiyang, Peoples R China.; Tian, Y (通讯作者)，Guizhou Univ, Sch Med, Guiyang, Peoples R China."

来源：BMC UROLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001162595200002

JCR分区：Q3

影响因子：1.7

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Prostatic fibrosis; Metabolic syndrome; Lower urinary tract symptoms

摘要："Background Prostatic fibrosis, characterized by the accumulation of myofibroblasts and collagen deposition, is closely associated with LUTS and may lead to mechanical obstruction of the urethra. Additionally, Metabolic Syndrome (MetS), characterized by central obesity, high blood sugar, lipid metabolism disorders, and hypertension, is increasingly recognized as a proinflammatory condition linked to prostate inflammation. Methods Clinical data from 108 subjects who underwent transurethral resection of the prostate or bipolar plasmakinetic enucleation of the prostate were prospectively collected between June 2021 and August 2022. Patients were divided in two groups according to whether or not they had a diagnosis of MetS. Specimens were stained with Masson trichrome and the periurethral prostatic fibrosis extent was evaluated using quantitative morphometry. Results Forty-three patients (39.8%) were diagnosed with MetS. Patients with MetS showed a significantly greater extent of prostatic fibrosis than the others (68.1 +/- 17.1% vs. 42.5 +/- 18.2%, P < 0.001), and there was a positive correlation between the number of positive MetS parameters and the extent of prostatic fibrosis (R-2 = 0.4436, P < 0.001). Multivariate regression analysis revealed that central obesity (B = 2.941, 95% confidence interval, 1.700-3.283), elevated fasting glucose (B = 1.036, 95% confidence interval, 0.293-1.780), reduced HDL cholesterol (B = 0.910, 95% confidence interval, 0.183-1.636) and elevated triglycerides (B = 1.666, 95% confidence interval, 0.824-2.508) were positively correlated to prostatic fibrosis. Elevated blood pressure, however, was unrelated to prostatic fibrosis (B = 0.009, 95% confidence interval, -0.664-0.683). Conclusions The present findings suggest that prostatic fibrosis is positively correlated with MetS and its components including central obesity, elevated fasting glucose, reduced high density lipoprotein cholesterol and elevated triglycerides."

基金机构：Science and Technology Program of Guizhou Province

基金资助正文：Not applicable.