New tricks for old drugs- praziquantel ameliorates bleomycin-induced pulmonary fibrosis in mice

作者全名："Zeng, Yanjun; Hu, Rui; Ma, Wei; Ding, Ying; Zhou, Yi; Peng, Xin; Feng, Lixin; Cheng, Qingmei; Luo, Ziqiang"

作者地址："[Luo, Ziqiang] Cent South Univ, Xiangya Sch Med, Dept Physiol, 110 Xiangya Rd, Changsha 410078, Peoples R China; [Zeng, Yanjun; Ma, Wei] South China Univ Technol, Guangzhou Peoples Hosp 1, Sch Med, Dept Geriatr Med, Guangzhou, Peoples R China; [Hu, Rui] Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing, Peoples R China; [Ding, Ying; Zhou, Yi; Peng, Xin] Cent South Univ, Xiangya Sch Med, Changsha, Peoples R China; [Feng, Lixin] Zhengzhou Univ, Zhengzhou Cent Hosp, Dept Rheumatol & Immunol, Zhengzhou, Peoples R China; [Cheng, Qingmei] Cent South Univ, Xiangya Hosp, Hunan Key Lab Joint Degenerat & Injury, 87 Xiangya Rd, Changsha 410008, Peoples R China"

通信作者："Luo, ZQ (通讯作者)，Cent South Univ, Xiangya Sch Med, Dept Physiol, 110 Xiangya Rd, Changsha 410078, Peoples R China.; Cheng, QM (通讯作者)，Cent South Univ, Xiangya Hosp, Hunan Key Lab Joint Degenerat & Injury, 87 Xiangya Rd, Changsha 410008, Peoples R China."

来源：BMC PHARMACOLOGY & TOXICOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001162676400001

JCR分区：Q2

影响因子：2.8

年份：2024

卷号：25

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Praziquantel; Pulmonary fibrosis; Collagen deposition; TGF-beta; Macrophage polarization

摘要："Background Pulmonary fibrosis is a chronic progressive disease with complex pathogenesis, short median survival time, and high mortality. There are few effective drugs approved for pulmonary fibrosis treatment. This study aimed to evaluate the effect of praziquantel (PZQ) on bleomycin (BLM)-induced pulmonary fibrosis. Methods In this study, we investigated the role and mechanisms of PZQ in pulmonary fibrosis in a murine model induced by BLM. Parameters investigated included survival rate, lung histopathology, pulmonary collagen deposition, mRNA expression of key genes involved in pulmonary fibrosis pathogenesis, the activity of fibroblast, and M2/M1 macrophage ratio. Results We found that PZQ improved the survival rate of mice and reduced the body weight loss induced by BLM. Histological examination showed that PZQ significantly inhibited the infiltration of inflammatory cells, collagen deposition, and hydroxyproline content in BLM-induced mice. Besides, PZQ reduced the expression of TGF-beta and MMP-12 in vivo and inhibited the proliferation of fibroblast induced by TGF-beta in vitro. Furthermore, PZQ affected the balance of M2/M1 macrophages. Conclusions Our study demonstrated that PZQ could ameliorate BLM-induced pulmonary fibrosis in mice by affecting the balance of M2/M1 macrophages and suppressing the expression of TGF-beta and MMP-12. These findings suggest that PZQ may act as an effective anti-fibrotic agent for preventing the progression of pulmonary fibrosis."

基金机构："Science and Technology Projects in Guangzhou [202201010012, 202203010099, 20220120262]; Guangzhou Key Discipline of Medicine (Geriatric Medicine) [ZDXK202103]"

基金资助正文："This study was supported by Science and Technology Projects in Guangzhou (No.202201010012, No.202203010099, No.20220120262) and Guangzhou Key Discipline of Medicine (Geriatric Medicine, ZDXK202103)."