Investigating the Causal Relationship Between Sleep Behaviors and Primary Open-Angle Glaucoma: A Bidirectional Two-Sample Mendelian Randomization Study

作者全名："Zhang, Jun; Chen, Xiaoyan; Zhu, Yan; Wan, Shanshan; Hu, Shuqiong; Yang, Yanning"

作者地址："[Zhang, Jun; Zhu, Yan; Wan, Shanshan; Yang, Yanning] Wuhan Univ, Renmin Hosp, Dept Ophthalmol, Jiefang Rd 238, Wuhan, Hubei, Peoples R China; [Chen, Xiaoyan] Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Hu, Shuqiong] Wuhan Univ, Wuhan Aier Eye Hosp, Aier Eye Hosp, Wuhan, Hubei, Peoples R China"

通信作者："Yang, YN (通讯作者)，Wuhan Univ, Renmin Hosp, Dept Ophthalmol, Jiefang Rd 238, Wuhan, Hubei, Peoples R China."

来源：NATURE AND SCIENCE OF SLEEP

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001162987100001

JCR分区：Q2

影响因子：3

年份：2024

卷号：16

期号：　

开始页：143

结束页：153

文献类型：Article

关键词：genome-wide association study; mendelian randomization; sleep behaviors; primary open-angle glaucoma; risk factors

摘要："Background: Although previous studies of sleep -related behaviors in relation to primary open -angle glaucoma (POAG) have been noted, the causal relationship remains unclear. The purpose of our present study was to investigate the relationships of genetically predicted sleep traits with POAG using a two -sample bidirectional Mendelian randomization (MR) method. Methods: Summary -level data collected from publicly available genome-wide association studies (GWAS) of European decent were applied for the bidirectional MR analysis. After quality control steps, independent single -nucleotide polymorphisms for eight sleep behaviors and POAG were selected as the genetic instruments. The inverse -variance weighted (IVW) approach was adopted as the primary method, which was complemented by a series of sensitivity analyses to assess the robustness of the results by estimating heterogeneity and pleiotropy. Multivariable MR (MVMR) was used to assess the direct effect of sleep traits on POAG, after adjusting for several confounding factors. Results: Our investigation revealed a positive correlation between genetically predicted ease of getting up in the morning and sleep duration and POAG using the IVW method (odds ratio (OR)=1.78, 95% confidence interval (CI):1.29-2.46, P = 4.33x 10(-4); OR = 1.66, 95% CI:1.18-2.34, P = 3.38x10(-3), respectively). Other supplementary MR methods also confirmed similar results. Moreover, the MVMR results also revealed that the adverse effects of these two sleep traits on POAG persisted after adjusting for body mass index, smoking, drinking, and education (all P < 0.05). Conversely, the relationships between genetic liability of POAG and different sleep behaviors were not statistically significant in the reverse -direction MR estimate (all P > 0.05). Conclusion: Our study demonstrated that genetic prediction of getting up easily in the morning or sleep duration were associated with a higher risk of POAG, but not vice versa, in a European population. Further validation and clinical interventions are required to offer potential strategies to prevent and manage POAG."

基金机构：Fundamental Research Funds for Central Universities [2042023kf0047]; National Natural Science Foundation of China [82301193]; Hubei Provincial Natural Science Foundation of China [2023AFB223]

基金资助正文：This work was supported by Fundamental Research Funds for Central Universities (2042023kf0047); National Natural Science Foundation of China (82301193); and Hubei Provincial Natural Science Foundation of China (2023AFB223).