The effect of transcranial direct current stimulation (tDCS) on cognitive function recovery in patients with depression following electroconvulsive therapy (ECT): protocol for a randomized controlled trial

作者全名："Hu, Renqin; Li, Junyao; Lu, Yulin; Luo, Huirong; Zhang, Yinlin; Wang, Xueqian; Zhang, Zheng; Luo, Qinghua"

作者地址："[Hu, Renqin; Li, Junyao; Luo, Huirong; Zhang, Yinlin; Wang, Xueqian; Zhang, Zheng; Luo, Qinghua] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Lu, Yulin] Peoples Hosp Chongqing Banan Dist, Dept Psychiat, Chongqing, Peoples R China"

通信作者："Luo, QH (通讯作者)，Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：BMC PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001163689000007

JCR分区：Q2

影响因子：3.4

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Electroconvulsive therapy (ECT); Transcranial direct current stimulation (tDCS); Depressive Disorder; Dorsolateral prefrontal cortex (DLPFC); Cognitive side effects; Cambridge Neuropsychological Test Automated Battery (CANTAB)

摘要："Background Electroconvulsive therapy (ECT) is a highly effective treatment for depressive disorder. However, the use of ECT is limited by its cognitive side effects (CSEs), and no specific intervention has been developed to address this problem. As transcranial direct current stimulation (tDCS) is a safe and useful tool for improving cognitive function, the main objective of this study was to explore the ability to use tDCS after ECT to ameliorate the cognitive side effects. Methods 60 eligible participants will be recruited within two days after completing ECT course and randomly assigned to receive either active or sham stimulation in a blinded, parallel-design trial and continue their usual pharmacotherapy. The tDCS protocol consists of 30-min sessions at 2 mA, 5 times per week for 2 consecutive weeks, applied through 15-cm2 electrodes. An anode will be placed over the left dorsolateral prefrontal cortex (DLPFC), and a cathode will be placed over the right supraorbital cortex. Cognitive function and depressive symptoms will be assessed before the first stimulation (T0), after the final stimulation (T1), 2 weeks after the final stimulation (T2), and 4 weeks after the final stimulation (T3) using the Cambridge Neuropsychological Test Automated Battery (CANTAB). Discussion We describe a novel clinical trial to explore whether the administration of tDCS after completing ECT course can accelerates recovery from the CSEs. We hypothesized that the active group would recover faster from the CSEs and be superior to the sham group. If our hypothesis is supported, the use of tDCS could benefit eligible patients who are reluctant to receive ECT and reduce the risk of self-inflicted or suicide due to delays in treatment."

基金机构："This study was supported by the Program for Youth Innovation in Future Medicine, Chongqing Medical University"

基金资助正文：The authors wish to express their gratitude to both the study participants and research assistants for their valuable dedication and substantial contributions.