Oncological features and prognosis of colorectal cancer in human immunodeficiency virus-positive patients: A retrospective study

作者全名："Yang, Fu-Yu; He, Fan; Chen, De-Fei; Tang, Cheng-Lin; Woraikat, Saed; Li, Yao; Qian, Kun"

作者地址："[Yang, Fu-Yu; He, Fan; Chen, De-Fei; Tang, Cheng-Lin; Woraikat, Saed; Qian, Kun] Chongqing Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Li, Yao] Chongqing Publ Hlth Med Ctr, Dept Gen Surg, Chongqing 400036, Peoples R China"

通信作者："Qian, K (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：WORLD JOURNAL OF GASTROINTESTINAL SURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001163817100015

JCR分区：Q3

影响因子：2

年份：2024

卷号：16

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Colorectal cancer; Human immunodeficiency virus; Propensity score matching; Oncological features; Surgical safety; Prognosis

摘要："BACKGROUND Due to the prolonged life expectancy and increased risk of colorectal cancer (CRC) among patients with human immunodeficiency virus (HIV) infection, the prognosis and pathological features of CRC in HIV-positive patients require examination. AIM To compare the differences in oncological features, surgical safety, and prognosis between patients with and without HIV infection who have CRC at the same tumor stage and site. METHODS In this retrospective study, we collected data from HIV-positive and -negative patients who underwent radical resection for CRC. Using random stratified sampling, 24 HIV-positive and 363 HIV-negative patients with colorectal adenocarcinoma after radical resection were selected. Using propensity score matching, we selected 72 patients, matched 1:2 (HIV-positive:negative = 24:48). Differences in basic characteristics, HIV acquisition, perioperative serological indicators, surgical safety, oncological features, and long-term prognosis were compared between the two groups. RESULTS Fewer patients with HIV infection underwent chemotherapy compared to patients without. HIV-positive patients had fewer preoperative and postoperative leukocytes, fewer preoperative lymphocytes, lower carcinoembryonic antigen levels, more intraoperative blood loss, more metastatic lymph nodes, higher node stage, higher tumor node metastasis stage, shorter overall survival, and shorter progression-free survival compared to patients who were HIV-negative. CONCLUSION Compared with CRC patients who are HIV-negative, patients with HIV infection have more metastatic lymph nodes and worse long-term survival after surgery. Standard treatment options for HIV-positive patients with CRC should be explored."

基金机构：General Plan of the Future Medical Youth Innovation Team Development Support Plan of Chongqing Medical University [03030299QC-W0007]

基金资助正文："Supported by General Plan of the Future Medical Youth Innovation Team Development Support Plan of Chongqing Medical University, No. 03030299QC-W0007."