Biomimetic nanotherapeutics for homotypic-targeting photothermal/ chemotherapy of oral cancer

作者全名："Li, Hongjiao; Zhu, Li; Zhang, Yao; Yang, Lin; Wu, Wei; Yang, Deqin"

作者地址："[Li, Hongjiao; Zhang, Yao; Yang, Lin; Yang, Deqin] Chongqing Med Univ, Dept Endodont, Stomatol Hosp, Chongqing 404100, Peoples R China; [Li, Hongjiao; Zhang, Yao; Yang, Lin; Yang, Deqin] Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Stomatol Hosp, Chongqing 404100, Peoples R China; [Li, Hongjiao; Zhang, Yao; Yang, Lin; Yang, Deqin] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 404100, Peoples R China; [Li, Hongjiao; Yang, Lin; Yang, Deqin] Chongqing Key Lab Oral Dis & Biomed Sci, 426 Songshi North Rd, Chongqing 401147, Peoples R China; [Zhu, Li; Wu, Wei] Chongqing Univ, Bioengn Coll, State & Local Joint Engn Lab Vasc Implants, Key Lab Biorheol Sci & Technol,Minist Educ, Chongqing 400044, Peoples R China; [Wu, Wei] Jin Feng Lab, Chongqing 401329, Peoples R China"

通信作者："Yang, DQ (通讯作者)，Chongqing Med Univ, Dept Endodont, Stomatol Hosp, Chongqing 404100, Peoples R China.; Wu, W (通讯作者)，Chongqing Univ, Bioengn Coll, State & Local Joint Engn Lab Vasc Implants, Key Lab Biorheol Sci & Technol,Minist Educ, Chongqing 400044, Peoples R China."

来源：JOURNAL OF CONTROLLED RELEASE

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001165923500001

JCR分区：Q1

影响因子：10.5

年份：2024

卷号：366

期号：　

开始页：28

结束页：43

文献类型：Article

关键词：Oral squamous cell carcinoma; Biomimetic; Target drug delivery; Chemotherapy; Photothermal therapy

摘要："Given the inherent complexity of cancer treatment and the limitations of singular therapeutic modalities, the development of an optimal nanocarrier system capable of facilitating synergistic organic therapy remains a profound challenge. Herein, a synergetic chemo/photothermal therapy nanoplatform was exploited to specifically tailor for the augmented treatment of oral cancer. A cancer cell membrane-camouflaged nanocarrier was developed with a polymeric core encapsulating doxorubicin (DOX). The designed nanoparticles (CC@DOXNPs) inherited the functional membrane proteins from the source cancer cells, endowing their remarkable ability to selectively target cancer cells delivery both in vitro and in vivo. Moreover, indocyanine green (ICG), modified with the phospholipid polymer DSPE-PEG2000, was introduced into the cancer cell membrane to enable photothermal therapy. Remarkably, as evaluated in a preclinical subcutaneous and orthotopic mice model of oral cancer, biomimetic composite nanotherapeutics (lip-CC@DOXNPs) could significantly accumulate into tumor lesion and effectively suppress tumor growth under the near-infrared (NIR, 808 nm) irradiation, without causing the undesirable systematic toxicity. Moreover, RNA sequence analyses indicated that chemo/photothermal therapy triggers the intrinsic mitochondria-mediated apoptosis through the p53 signaling pathway. Combined with gene expression results, this intrinsic mitochondria-mediated apoptosis pathway was further demonstrated. Collectively, this multifaceted nanoplatforms possess a remarkable capability for tumor-targeting drug delivery, and the proficient photothermal conversion ability, rendering them an ideal therapeutic approach for oral cancer treatment."

基金机构："National Natural Science Foundation of China [31970783, 32270888]; Program for Top talent Distin- guished Progressor from Chongqing Medical University [[2021] 215]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (31970783 and 32270888) , Program for Top talent Distin- guished Progressor from Chongqing Medical University (NO. [2021] 215) ."