Ultrasound-nanovesicles interplay for theranostics

作者全名："Liu, Jingyi; You, Qing; Liang, Fuming; Ma, Lilusi; Zhu, Ling; Wang, Chen; Yang, Yanlian"

作者地址："[Liu, Jingyi; You, Qing; Liang, Fuming; Ma, Lilusi; Zhu, Ling; Wang, Chen; Yang, Yanlian] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechnol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; [Liu, Jingyi; Ma, Lilusi; Zhu, Ling; Wang, Chen; Yang, Yanlian] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Liang, Fuming] Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Zhu, L; Wang, C; Yang, YL (通讯作者)，Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechnol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.; Zhu, L; Wang, C; Yang, YL (通讯作者)，Univ Chinese Acad Sci, Beijing 100049, Peoples R China."

来源：ADVANCED DRUG DELIVERY REVIEWS

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001166726200001

JCR分区：Q1

影响因子：15.2

年份：2024

卷号：205

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Nanovesicles; Ultrasound; Formation; Deliver; Disease; Treatment; Diagnosis

摘要："Nanovesicles (NVs) are widely used in the treatment and diagnosis of diseases due to their excellent vascular permeability, good biocompatibility, high loading capacity, and easy functionalization. However, their yield and in vivo penetration depth limitations and their complex preparation processes still constrain their application and development. Ultrasound, as a fundamental external stimulus with deep tissue penetration, concentrated energy sources, and good safety, has been proven to be a patient-friendly and highly efficient strategy to overcome the restrictions of traditional clinical medicine. Recent research has shown that ultrasound can drive the generation of NVs, increase their yield, simplify their preparation process, and provide direct therapeutic effects and intelligent control to enhance the therapeutic effect of NVs. In addition, NVs, as excellent drug carriers, can enhance the targeting efficiency of ultrasound-based sonodynamic therapy or sonogenetic regulation and improve the accuracy of ultrasound imaging. This review provides a detailed introduction to the classification, generation, and modification strategies of NVs, emphasizing the impact of ultrasound on the formation of NVs and summarizing the enhanced treatment and diagnostic effects of NVs combined with ultrasound for various diseases."

基金机构：Strategic Priority Research Program of Chinese Academy of Science [XDB36000000]; National Natural Sci- ence Foundation of China [31971295]

基金资助正文："This work was supported by the Strategic Priority Research Program of Chinese Academy of Science (XDB36000000) , National Natural Sci- ence Foundation of China (31971295) ."