Prevalence of small vessel disease and incidental DWI-positive lesions in patients with aneurysmal subarachnoid hemorrhage versus intracerebral hemorrhage

作者全名："Wang, Zi-Jie; Hu, Xiao; Xie, Yan-Fang; Yao, Wen-Jun; Deng, Lan; Li, Zuo-Qiao; Pu, Ming-Jun; Lv, Xin-Ni; Hu, Zi-Cheng; Zhang, Jiang-Tao; Li, Qi"

作者地址："[Wang, Zi-Jie; Xie, Yan-Fang; Li, Qi] Second Affiliated Hosp Anhui Med Univ, Dept Neurol, Hefei, Anhui, Peoples R China; [Wang, Zi-Jie; Hu, Xiao; Deng, Lan; Li, Zuo-Qiao; Pu, Ming-Jun; Lv, Xin-Ni; Li, Qi] First Affiliated Hosp Chongqing Med Univ, Dept Neurol, Chongqing, Peoples R China; [Yao, Wen-Jun] Second Affiliated Hosp Anhui Med Univ, Dept Radiol, Hefei, Anhui, Peoples R China; [Hu, Zi-Cheng] Peoples Hosp Hechuan, Dept Neurol, Chongqing, Peoples R China; [Zhang, Jiang-Tao] Chengde Cent Hosp, Dept Neurol, Chengde, Hebei, Peoples R China; [Li, Qi] Chongqing Key Lab Cerebrovasc Dis Res, Chongqing, Peoples R China; [Li, Qi] Second Affiliated Hosp Anhui Med Univ, Dept Neurol, 678 Furong Rd, Hefei 230601, Anhui, Peoples R China"

通信作者："Li, Q (通讯作者)，Second Affiliated Hosp Anhui Med Univ, Dept Neurol, 678 Furong Rd, Hefei 230601, Anhui, Peoples R China."

来源：EUROPEAN STROKE JOURNAL

ESI学科分类：　

WOS号：WOS:001166766600001

JCR分区：Q1

影响因子：5.8

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Cerebral small vessel disease; intracerebral hemorrhage; MRI; subarachnoid hemorrhage

摘要："Introduction: Aneurysmal subarachnoid hemorrhage (aSAH) and intracerebral hemorrhage (ICH) are main forms of hemorrhagic stroke. Data regarding cerebral small vessel disease (SVD) burden and incidental small lesions on diffusion-weighted imaging (DWI) following aSAH are sparse. Patients and methods: We retrospectively analyzed a prospective cohort of aSAH and ICH patients with brain MRI within 30 days after onset from March 2015 to January 2023. White matter hyperintensity (WMH), lacune, perivascular space, cerebral microbleed (CMB), total SVD score, and incidental DWI lesions were assessed and compared between aSAH and ICH. Clinical and radiological characteristics associated with small DWI lesions in aSAH were investigated. Results: We included 180 patients with aSAH (median age [IQR] 53 [47-61] years) and 299 with ICH (63 [53-73] years). DWI lesions were more common in aSAH than ICH (47.8% vs 14.4%, p < 0.001). Higher total SVD score was associated with ICH versus aSAH irrespective of hematoma location, whereas DWI lesions and strictly lobar CMBs were correlated with aSAH. Multivariable analysis showed that shorter time from onset to MRI, anterior circulation aneurysm rupture, CMB >= 5, and total SVD score were associated with DWI lesions in aSAH. Discussion and conclusion: Incidental DWI lesions and strictly lobar CMBs were more frequent in aSAH versus ICH whereas ICH had higher SVD burden. Incidental DWI lesions in aSAH were associated with multiple clinical and imaging factors. Longitudinal studies to investigate the dynamic change and prognostic value of the covert hemorrhagic and ischemic lesions in aSAH seem justified."

基金机构："National Natural Science Foundation of China [82071337]; National Key R&D Program of China [2018YFC1312200, 2018YFC1312203]; Chongqing Science Fund for Distinguished Young Scholars [cstc2021j-cyj-jqX0029]; Chongqing High-end Young Investigator Project [2019GDRC005]; S&T Program of Hebei [20377764D]; Research Fund of Anhui Institute of Translational Medicine [2022zhyx-C38]"

基金资助正文："The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by National Natural Science Foundation of China (No. 82071337), the National Key R & D Program of China (No. 2018YFC1312200 and No. 2018YFC1312203), Chongqing Science Fund for Distinguished Young Scholars (No. cstc2021j-cyj-jqX0029), Chongqing High-end Young Investigator Project (No. 2019GDRC005), S & T Program of Hebei (No. 20377764D), and Research Fund of Anhui Institute of Translational Medicine (No. 2022zhyx-C38)."