Broad Elevation Projection Super-Resolution Ultrasound (BEP-SRUS) Imaging With a 1-D Unfocused Linear Array

作者全名："Wang, Bingxue; Riemer, Kai; Toulemonde, Matthieu; Yan, Jipeng; Zhou, Xiaowei; Smith, Cameron A. B.; Tang, Meng-Xing"

作者地址："[Wang, Bingxue; Riemer, Kai; Toulemonde, Matthieu; Yan, Jipeng; Tang, Meng-Xing] Imperial Coll London, Ultrasound Lab Imaging & Sensing, Dept Bioengn, London SW7 2AZ, England; [Zhou, Xiaowei] Chongqing Med Univ, State Key Lab Ultrasound Med & Engn, Chongqing 400014, Peoples R China; [Smith, Cameron A. B.] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA"

通信作者："Tang, MX (通讯作者)，Imperial Coll London, Ultrasound Lab Imaging & Sensing, Dept Bioengn, London SW7 2AZ, England."

来源：IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL

ESI学科分类：ENGINEERING

WOS号：WOS:001167033600008

JCR分区：Q1

影响因子：3

年份：2024

卷号：71

期号：2

开始页：255

结束页：265

文献类型：Article

关键词：Microbubble (MB) contrast agents; microvascular flow; super-resolution ultrasound (SRUS); ultrasound localization microscopy (ULM); ultrasound projection imaging

摘要："Super-resolution ultrasound (SRUS) through localizing spatially isolated microbubbles (MBs) has been demonstrated to overcome the wave diffraction limit and reveal the microvascular structure and flow information at the microscopic scale. However, 3-D SRUS imaging remains a challenge due to the fabrication and computational complexity of 2-D matrix array probes. Inspired by X-ray radiography which can present information within a volume in a single projection image with much simpler hardware than X-ray computerized tomography (CT), this study investigates the feasibility of broad elevation projection super-resolution (BEP-SR) ultrasound using a 1-D unfocused linear array. Both simulation and in vitro experiments were conducted on 3-D microvessel phantoms. In vivo demonstration was done on the Rabbit kidney. Data from a 1-D linear array with and without an elevational focus were synthesized by summing up row signals acquired from a 2-D matrix array with and without delays. A full 3-D reconstruction was also generated as the reference, using the same data of the 2-D matrix array but without summing row signals. Results show that using an unfocused 1-D array probe, BEP-SR can capture significantly more information within a volume in both vascular structure and flow velocity than the conventional 1-D elevational-focused probe. Compared with the 2-D projection image of the full 3-D SRUS results using the 2-D array probe with the same aperture size, the 2-D projection SRUS image of BEP-SR has similar volume coverage, using 32 folds fewer independent elements. This study demonstrates BEP-SR's ability of high-resolution imaging of microvascular structures and flow velocity within a 3-D volume at significantly reduced costs. The proposed BEP method could significantly benefit the clinical translation of the SRUS imaging technique by making it more affordable and repeatable."

基金机构：Chan Zuckerberg Initiative (CZI) Project

基金资助正文：No Statement Available