Multivalence Manganese Mediated Dual ROS Generator for Augmented Chemodynamic Therapy and Activated Antitumor Immunogenic Responses

作者全名："Huo, Linlin; Zhu, Shiqi; Zeng, Jie; Lin, Ruipeng; Chen, Wenwen; Li, Muyao; Sun, Xin; Tan, Mingya; Huang, Guoming; Xu, Kai; Zhao, Zhenghuan"

作者地址："[Huo, Linlin; Zhu, Shiqi; Zeng, Jie; Tan, Mingya; Zhao, Zhenghuan] Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China; [Lin, Ruipeng; Chen, Wenwen; Huang, Guoming] Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Peoples R China; [Li, Muyao] Chengdu Univ Tradit Chinese Med, Coll Life Sci & Med, Chengdu 610075, Peoples R China; [Sun, Xin] Army Med Univ, Daping Hosp, Dept Radiol, Chongqing 400042, Peoples R China; [Xu, Kai] Strateg Support Force Med Ctr, Dept Radiol, Beijing 100101, Peoples R China"

通信作者："Zhao, ZH (通讯作者)，Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China.; Xu, K (通讯作者)，Strateg Support Force Med Ctr, Dept Radiol, Beijing 100101, Peoples R China."

来源：ACS MATERIALS LETTERS

ESI学科分类：　

WOS号：WOS:001167204700001

JCR分区：Q1

影响因子：9.6

年份：2024

卷号：6

期号：3

开始页：885

结束页：895

文献类型：Article

关键词：　

摘要："The efficacy of chemodynamic therapy (CDT) and its potential to induce immunogenic cell death (ICD) are highly dependent on the types and efficiency of generated reactive oxygen species (ROS). Herein, we innovatively develop a manganese platinum (MnPt) nanozyme with dual ROS generation for magnetic resonance imaging guided CDT and ICD. The multivalence state of Mn ions authorizes MnPt to simultaneously generate hydroxyl radical and singlet oxygen under high H2O2 and acid condition, which obviously increases the types of ROS. Significantly, the mild photothermal conversion and enzyme-like activity endow MnPt to regulate tumor microenvironment and elevate the operating rate, further increasing the ROS generation efficiency and CDT efficacy in vitro/vivo. Moreover, the exaltation on both types and generation efficiency of ROS significantly enhances immunogenicity and initiates the immune response to limit tumor metastases. This study provides a highly practical strategy for the accurate diagnosis and efficient therapy of tumors."

基金机构："Chongqing High-level Personnel of Special Support Program [81971609]; National Natural Science Foundation of China [CQYC201905077]; Chongqing High-level Personnel of Special Support Program (Youth Top-notch Talent) [CXQT21017]; Creative Research Group of CQ University [W0105]; Program for Youth Innovation in Future Medicine, Chongqing Medical University"

基金资助正文："This work was supported by the National Natural Science Foundation of China (81971609), Chongqing High-level Personnel of Special Support Program (Youth Top-notch Talent CQYC201905077), Creative Research Group of CQ University (CXQT21017), and Program for Youth Innovation in Future Medicine, Chongqing Medical University (W0105)."