Causal influence of muscle weakness on cardiometabolic diseases and osteoporosis

作者全名："Mou, Xiaoqing; He, Bin; Zhang, Muzi; Zhu, Yong; Ou, Yunsheng; Chen, Xiaojun"

作者地址："[Mou, Xiaoqing] Southwest Med Univ, Dept Radiol, Affiliated Hosp, Luzhou, Sichuan, Peoples R China; [He, Bin; Zhang, Muzi; Zhu, Yong; Ou, Yunsheng] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing, Peoples R China; [Chen, Xiaojun] Southwest Med Univ, Dept Orthoped, Affiliated Tradit Chinese Med Hosp, Luzhou, Sichuan, Peoples R China"

通信作者："He, B (通讯作者)，Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing, Peoples R China.; Chen, XJ (通讯作者)，Southwest Med Univ, Dept Orthoped, Affiliated Tradit Chinese Med Hosp, Luzhou, Sichuan, Peoples R China."

来源：SCIENTIFIC REPORTS

ESI学科分类：Multidisciplinary

WOS号：WOS:001167946400031

JCR分区：Q1

影响因子：3.8

年份：2023

卷号：13

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："The causal roles of muscle weakness in cardiometabolic diseases and osteoporosis remain elusive. This two-sample Mendelian randomization (MR) study aims to explore the causal roles of muscle weakness in the risk of cardiometabolic diseases and osteoporosis. 15 single nucleotide polymorphisms (SNPs, P<5x10(-8)) associated with muscle weakness were used as instrumental variables. Genetic predisposition to muscle weakness led to increased risk of coronary artery disease (inverse variance weighted [IVW] analysis, beta-estimate: 0.095, 95% confidence interval [CI]: 0.023 to 0.166, standard error [SE]:0.036, P-value=0.009) and reduced risk of heart failure (weight median analysis, beta-estimate: - 0.137, 95% CI - 0.264 to - 0.009, SE:0.065, P-value=0.036). In addition, muscle weakness may reduce the estimated bone mineral density (eBMD, weight median analysis, beta-estimate: - 0.059, 95% CI - 0.110 to - 0.008, SE:0.026, P-value=0.023). We found no MR associations between muscle weakness and atrial fibrillation, type 2 diabetes or fracture. This study provides robust evidence that muscle weakness is causally associated with the incidence of coronary artery disease and heart failure, which may provide new insight to prevent and treat these two cardiometabolic diseases."

基金机构：Medical Research Project of Luzhou-Southwest Medical University [2019LZXNYDJ37]; Scientific Research Cultivation Project of The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University [2022-CXTD-08]; China Postdoctoral Science Foundation [2022M720602]; Chongqing Special Postdoctoral Science Foundation [XmT2022072]; Natural Science Foundation of Chongqing [cstc2019jcyj-msxmX0836]

基金资助正文："This study was funded by Medical Research Project of Luzhou-Southwest Medical University (2019LZXNYDJ37), Scientific Research Cultivation Project of The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University (2022-CXTD-08), China Postdoctoral Science Foundation (2022M720602), Chongqing Special Postdoctoral Science Foundation (XmT2022072), Natural Science Foundation of Chongqing (cstc2019jcyj-msxmX0836)."