Nano-Micron Combined Hydrogel Microspheres: Novel Answer for Minimal Invasive Biomedical Applications

作者全名："Liu, Jiacheng; Du, Chengcheng; Chen, Hong; Huang, Wei; Lei, Yiting"

作者地址："[Liu, Jiacheng; Du, Chengcheng; Chen, Hong; Huang, Wei; Lei, Yiting] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Orthoped Lab, Chongqing 400016, Peoples R China"

通信作者："Chen, H; Huang, W; Lei, YT (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Orthoped Lab, Chongqing 400016, Peoples R China."

来源：MACROMOLECULAR RAPID COMMUNICATIONS

ESI学科分类：CHEMISTRY

WOS号：WOS:001168394300001

JCR分区：Q2

影响因子：4.2

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：hydrogel microsphere; minimal invasive application; nano-material; nano-micron combination

摘要："Hydrogels, key in biomedical research for their hydrophilicity and versatility, have evolved with hydrogel microspheres (HMs) of micron-scale dimensions, enhancing their role in minimally invasive therapeutic delivery, tissue repair, and regeneration. The recent emergence of nanomaterials has ushered in a revolutionary transformation in the biomedical field, which demonstrates tremendous potential in targeted therapies, biological imaging, and disease diagnostics. Consequently, the integration of advanced nanotechnology promises to trigger a new revolution in the realm of hydrogels. HMs loaded with nanomaterials combine the advantages of both hydrogels and nanomaterials, which enables multifaceted functionalities such as efficient drug delivery, sustained release, targeted therapy, biological lubrication, biochemical detection, medical imaging, biosensing monitoring, and micro-robotics. Here, this review comprehensively expounds upon commonly used nanomaterials and their classifications. Then, it provides comprehensive insights into the raw materials and preparation methods of HMs. Besides, the common strategies employed to achieve nano-micron combinations are summarized, and the latest applications of these advanced nano-micron combined HMs in the biomedical field are elucidated. Finally, valuable insights into the future design and development of nano-micron combined HMs are provided. Dive into the cutting-edge world of biomedical research! Explore the evolution of hydrogel microspheres (HMs) and their fusion with nanomaterials, promising a revolutionary shift in healthcare. Uncover the potential of multifaceted functionalities-from targeted therapy to micro-robotics. Join in this comprehensive journey through nanomaterials, HMs preparation, and future applications. The future of biomedical innovation is now! image"

基金机构："National Natural Science Foundation of China; Life Science Institute of Chongqing Medical University [82302755, U22A20284]; National Natural Science Foundation of China, PRC"

基金资助正文："J.L. and C.D. contributed equally to this work. The authors acknowledge the support from the Life Science Institute of Chongqing Medical University. The authors thank Shuangquan Su for the support in creating the illustration and obtaining the publication and licensing rights from BioRender (BioRender.com). J.L. would like to express his gratitude to Yuanyuan Wang for her constant encouragement and support. This study was financially supported by the National Natural Science Foundation of China, PRC (82302755, U22A20284)."