TIM22 and TIM29 inhibit HBV replication by up-regulating SRSF1 expression

作者全名："Guo, Lin; Liu, Jia-jun; Long, Shao-yuan; Wang, Pei-yun; Li, Shan; Wang, Jin-lan; Wei, Xia-fei; Li, Jie; Lei, Ling; Huang, Ai-long; Hu, Jie-li"

作者地址："[Guo, Lin; Liu, Jia-jun; Long, Shao-yuan; Wang, Pei-yun; Wang, Jin-lan; Li, Jie; Huang, Ai-long; Hu, Jie-li] Chongqing Med Univ, Key Lab Mol Biol Infect Dis, Minist Educ, Chongqing, Peoples R China; [Guo, Lin] Chengdu Med Coll, Chengdu Peoples Hosp 7, Affiliated Canc Hosp, Dept Clin Lab, Chengdu, Peoples R China; [Li, Shan] Sixth Hosp Chengdu, Dept Clin Lab, Chengdu, Peoples R China; [Wei, Xia-fei] Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Inst Hepatol, Natl Clin Res Ctr Infect Dis, Shenzhen, Peoples R China; [Lei, Ling] Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Chongqing, Peoples R China"

通信作者："Huang, AL; Hu, JL (通讯作者)，Chongqing Med Univ, Key Lab Mol Biol Infect Dis, Minist Educ, Chongqing, Peoples R China.; Lei, L (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Chongqing, Peoples R China."

来源：JOURNAL OF MEDICAL VIROLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001168678200050

JCR分区：Q1

影响因子：6.8

年份：2024

卷号：96

期号：2

开始页：　

结束页：　

文献类型：Article

关键词：HBV; mitochondria; SRSF1; TIM22; TIM29

摘要："Hepatitis B virus (HBV) infection is a serious global health problem. After the viruses infect the human body, the host can respond to the virus infection by coordinating various cellular responses, in which mitochondria play an important role. Evidence has shown that mitochondrial proteins are involved in host antiviral responses. In this study, we found that the overexpression of TIM22 and TIM29, the members of the inner membrane translocase TIM22 complex, significantly reduced the level of intracellular HBV DNA and RNA and secreted HBV surface antigens and E antigen. The effects of TIM22 and TIM29 on HBV replication and transcription is attributed to the reduction of core promoter activity mediated by the increased expression of SRSF1 which acts as a suppressor of HBV replication. This study provides new evidence for the critical role of mitochondria in the resistance of HBV infection and new targets for the development of treatment against HBV infection."

基金机构："National Key R&D Program of China [2022YFA1303600]; Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0298]; Chongqing Municipality Education Commission [KJZD-K202200409]; The 111 Project [D20028]; Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University [202104]; CQMU Program for Youth Innovation in Future Medicine [W0049]"

基金资助正文："National Key R & D Program of China, Grant/Award Number: (2022YFA1303600); Natural Science Foundation of Chongqing, Grant/Award Number: (cstc2021jcyj-msxmX0298); Chongqing Municipality Education Commission, Grant/Award Number:(KJZD-K202200409); the 111 Project, Grant/Award Number: (D20028); Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Grant/Award Number:(202104); CQMU Program for Youth Innovation in Future Medicine, Grant/Award Number: (W0049)"