Risk factors for mortality in pseudomonas aeruginosa bacteremia in children

作者全名："Chen, Jian; Huang, Haixin; Liu, Chengjun; Fu, Yue-qiang"

作者地址："[Chen, Jian; Huang, Haixin; Liu, Chengjun; Fu, Yue-qiang] Chongqing Med Univ, Childrens Hosp, Minist Educ, Dept Crit Care Med,Natl Clin Res Ctr Child Hlth &, Chongqing 400014, Peoples R China; [Fu, Yue-qiang] Chongqing Med Univ, Childrens Hosp, Dept Crit Care Med, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China"

通信作者："Fu, YQ (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Crit Care Med, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China."

来源：PEDIATRICS AND NEONATOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001170545200001

JCR分区：Q2

影响因子：2.1

年份：2024

卷号：65

期号：1

开始页：31

结束页：37

文献类型：Article

关键词：bacteremia; children; mortality; Pseudomonas aeruginosa

摘要："Background: The incidence of Pseudomonas aeruginosa (P. aeruginosa) bacteremia in children ranks third to fourth among gram -negative bacilli bacteremia, which is one of the main conditional pathogens in hospitals. This study aimed to identify the clinical characteristics and risk factors of 60 -day in -hospital mortality in children with P. aeruginosa bacteremia. Methods: This retrospective study was conducted in a tertiary pediatric hospital between January 2015 and December 2021 including children with P. aeruginosa bacteremia. Kaplan - Meier survival analysis was used to investigate the time -to -event outcomes. Logistic regression was used to explore the independent risk factors for 60 -day mortality. Results: Overall, 75 patients with P. aeruginosa bacteremia episodes were identified. Immunosuppression (52%) was the most common underlying condition, followed by neutropenia (50.7%) and hematological malignancies (48%). Among 75 patients with P. aeruginosa bacteremia, 25 (33.3%) had septic shock, 30 (40%) had respiratory failure, and 20 (26.7%) had liver function impairment. The 60 -day in -hospital mortality was 17.3%. In multivariate analysis, independent risk factors for 60 -day mortality were respiratory failure [odds ratio (OR) 39.329; 95% CI:3.212 - 481.48, P = 0.004) and liver function impairment (OR 17.925; 95% CI:2.909-139.178, P = 0.002). Conclusion: Respiratory failure and liver function impairment seem to be related to poor prognosis in children with P. aeruginosa bacteremia. Copyright (c) 2023, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/ by-nc-nd/4.0/)."

基金机构：Program for Youth Innovation in Future Medicine from Chongqing Medical University: Basic and Clinical Study of Critical Illness in Children [2021-W0111]

基金资助正文：The Program for Youth Innovation in Future Medicine from Chongqing Medical University: Basic and Clinical Study of Critical Illness in Children (2021-W0111 to YF) .