"Association between alcohol consumption and risk of hyperuricaemia among adults: a large cross-sectional study in Chongqing, China"

作者全名："Chen, Siyu; Ding, Rui; Tang, Xiaojun; Chen, Liling; Luo, Qinwen; Xiao, Meng; Ding, Xianbin; Peng, Bin"

作者地址："[Chen, Siyu; Tang, Xiaojun; Luo, Qinwen; Xiao, Meng; Peng, Bin] Chongqing Med Univ, Sch Publ Hlth, Chongqing, Peoples R China; [Ding, Rui] Chongqing Med Univ, Clin Med Coll 1, Chongqing, Peoples R China; [Chen, Liling; Ding, Xianbin] Chongqing Ctr Dis Control & Prevent, Inst Chron Noncommunicable Dis Control & Prevent, Chongqing, Peoples R China"

通信作者："Peng, B (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Chongqing, Peoples R China.; Ding, XB (通讯作者)，Chongqing Ctr Dis Control & Prevent, Inst Chron Noncommunicable Dis Control & Prevent, Chongqing, Peoples R China."

来源：BMJ OPEN

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001171115000129

JCR分区：Q1

影响因子：2.4

年份：2023

卷号：13

期号：12

开始页：　

结束页：　

文献类型：Article

关键词：public health; epidemiology; adult nephrology

摘要："ObjectiveTo investigate the relationship between alcohol consumption and hyperuricaemia (HUA), we conducted a study based on a large population.SettingCross-sectional study.ParticipantsA total of 20 833 participants aged 30-79 years were enrolled in the China Multi-Ethnic Cohort, Chongqing region.OutcomesThe serum level of uric acid, fasting blood glucose and blood lipids were tested. Basic demographic statistics such as age, gender, marital status, education level, family annual income and the detail information of alcohol consumption were collected using a standardised questionnaire.ResultsAfter controlling for potential confounders, compared with participants who never consumed alcohol, participants who drank 3-5 days per week had the highest risk of HUA (OR: 1.51, 95% CI: 1.25 to 1.82) and those who drank alcohol harmfully had the highest risk of HUA (OR: 1.81, 95% CI: 1.41 to 2.32). In addition, we found that those who drank moderately had no significant association with risk of HUA. However, among men, compared with participants who never consumed alcohol, those who drank moderately was also a risk factor of HUA (OR: 1.23, 95% CI: 1.03 to 1.46) and those who drank alcohol harmfully had the highest risk of HUA (OR: 2.13, 95% CI: 1.64 to 2.78). Compared with participants who drank alcohol moderately, the OR (95% CI) for those who drank alcohol harmfully had the highest risk of HUA was 1.88 (1.42 to 2.48), and the corresponding OR (95% CI) for each level increment in the degree of alcohol consumption was 1.22 (1.12 to 1.33). Among men, compared with participants who drank alcohol moderately, those who drank alcohol harmfully had the highest risk of HUA (OR: 1.93, 95% CI: 1.45 to 2.57), as well as the corresponding OR (95% CI) for each level increment in the degree of alcohol consumption was 1.24 (1.13 to 1.35).ConclusionThis study suggested that the frequency and degree of alcohol consumption may be the risk factors for HUA, especially in males."

基金机构：National Key Research and Development Programme of China [2017YFC0907303]; National Natural Science Foundation of China [82273739]; [ZHYX202127]

基金资助正文："This work was supported by the National Key Research and Development Programme of China (grant number:2017YFC0907303), National Natural Science Foundation of China (grant number:82273739), Comparison of diabetes drug utilisation evaluation and personalised efficacy evaluation model based on big data (grant number: ZHYX202127)."