Cross-sectional studies of the causal link between asthma and osteoporosis: insights from Mendelian randomization and bioinformatics analysis

作者全名："Chen, Lexin; Li, Can; Chen, Hangang; Xie, Yangli; Su, Nan; Luo, Fengtao; Huang, Junlan; Zhang, Ruobin; Chen, Lin; Chen, Bo; Yang, Jing"

作者地址："[Chen, Lexin; Li, Can; Chen, Hangang; Xie, Yangli; Su, Nan; Luo, Fengtao; Huang, Junlan; Zhang, Ruobin; Chen, Lin; Chen, Bo; Yang, Jing] Army Med Univ, Ctr Osteoporosis & Bone Dev, Lab Injury Repair & Rehabil Med, State Key Lab Trauma & Chem Poisoning,Daping Hosp, Chongqing 400042, Peoples R China; [Chen, Lexin; Chen, Hangang] Chongqing Med Univ, Chongqing 400010, Peoples R China"

通信作者："Chen, B; Yang, J (通讯作者)，Army Med Univ, Ctr Osteoporosis & Bone Dev, Lab Injury Repair & Rehabil Med, State Key Lab Trauma & Chem Poisoning,Daping Hosp, Chongqing 400042, Peoples R China."

来源：OSTEOPOROSIS INTERNATIONAL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001171667800001

JCR分区：Q1

影响因子：4.2

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Asthma; Bone turnover; Cross-sectional studies; Mendelian randomization; Osteoporosis

摘要："The study, using data from Chongqing, China, and employing Mendelian randomization along with bioinformatics, establishes a causal link between asthma and osteoporosis, beyond glucocorticoid effects. Asthma may contribute to osteoporosis by accelerating bone turnover through inflammatory factors, disrupting the coupling between osteoblasts and osteoclasts, ultimately leading to osteoporosis.IntroductionAsthma and osteoporosis are prevalent health conditions with substantial public health implications. However, their potential interplay and the underlying mechanisms have not been fully elucidated. Previous research has primarily focused on the impact of glucocorticoids on osteoporosis, often overlooking the role of asthma itself.MethodsWe conducted a multi-stage stratified random sampling in Chongqing, China and excluded individuals with a history of glucocorticoid use. Participants underwent comprehensive health examinations, and their clinical data, including asthma status, were recorded. Logistic regression and Mendelian randomization were employed to investigate the causal link between asthma and osteoporosis. Furthermore, bioinformatics analyses and serum biomarker assessments were conducted to explore potential mechanistic pathways.ResultsWe found a significant association between asthma and osteoporosis, suggesting a potential causal link. Mendelian Randomization analysis provided further support for this causal link. Bioinformatics analyses revealed that several molecular pathways might mediate the impact of asthma on bone health. Serum alkaline phosphatase levels were significantly elevated in the asthma group, suggesting potential involvement in bone turnover.ConclusionOur study confirms a causal link between asthma and osteoporosis and highlights the importance of considering asthma in osteoporosis prediction models. It also suggests that asthma may accelerate osteoporosis by increasing bone turnover through inflammatory factors, disrupting the coupling between osteoblasts and osteoclasts, ultimately leading to bone loss."

基金机构：Army Medical University Daping Hospital: Third Military Medical University Daping Hospital and Research Institute of Surgery

基金资助正文：No Statement Available