The role of NLRP6 in the development and progression of neurological diseases

作者全名：Guo, Yiming; Song, Jiaqi; Yan, Mengyu; Chen, Yingxi; Huang, Lihong; Liu, Jiarui; He, Yurou; Lue, Yang; Yu, Weihua

作者地址：[Guo, Yiming; Song, Jiaqi; Yan, Mengyu; Chen, Yingxi; Huang, Lihong; He, Yurou; Yu, Weihua] Chongqing Med Univ, Inst Neurosci, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Liu, Jiarui; Lue, Yang] Chongqing Med Univ, Dept Geriatr, Affiliated Hosp 1, Chongqing 400016, Peoples R China

通信作者：Yu, WH (通讯作者)，Chongqing Med Univ, Inst Neurosci, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.

来源：MOLECULAR BIOLOGY REPORTS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001172939200012

JCR分区：Q3

影响因子：2.6

年份：2024

卷号：51

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Neurological disease; NLRP6 inflammasome; Caspase-1; Caspase-11; IL-1 beta; IL-18

摘要：The nervous system possesses the remarkable ability to undergo changes in order to store information; however, it is also susceptible to damage caused by invading pathogens or neurodegenerative processes. As a member of nucleotide-binding oligomerization domain-like receptor (NLR) family, the NLRP6 inflammasome serves as a cytoplasmic innate immune sensor responsible for detecting microbe-associated molecular patterns. Upon activation, NLRP6 can recruit the adapter protein apoptosis-associated speck-like protein (ASC) and the inflammatory factors caspase-1 or caspase-11. Consequently, inflammasomes are formed, facilitating the maturation and secretion of pro-inflammatory cytokines such as inflammatory factors-18 (IL-18) and inflammatory factors-1 beta (IL-1 beta). Precise regulation of NLRP6 is crucial for maintaining tissue homeostasis, as dysregulated inflammasome activation can contribute to the development of various diseases. Furthermore, NLRP6 may also play a role in the regulation of extraintestinal diseases. In cells of the brain, such as astrocytes and neurons, NLRP6 inflammasome are also present. Here, the assembly and subsequent activation of caspase-1 mediated by NLRP6 contribute to disease progression. This review aims to discuss the structure and function of NLRP6, explain clearly the mechanisms that induce and activate NLRP6, and explore its role within the central and peripheral nervous system.

基金机构：National Natural Science Foundation of China [81871019, 81671286]; Graduate Research Innovation Project of Chongqing [CYS23322]

基金资助正文：This study was supported by grants from the National Natural Science Foundation of China (81871019, 81671286) and Graduate Research Innovation Project of Chongqing (CYS23322).