Allergic rhinitis as a predictor of moderate-to-severe paediatric obstructive sleep apnoea

作者全名："Yang, Bo; Zou, Qiyuan; Wang, Fan; Pang, Ying; Wei, Ping; Xing, Yuhan"

作者地址："[Yang, Bo] Chongqing Med Univ, Dept Otorhinolaryngol, Affiliated Hosp 1, Chongqing, Peoples R China; [Zou, Qiyuan; Wang, Fan; Pang, Ying; Wei, Ping] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Otorhinolaryngol,Chongqing Key Lab Pediat, Minist Educ Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China; [Xing, Yuhan] Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Shenzhen 518107, Peoples R China; [Xing, Yuhan] Qingdao Univ, Qingdao Women & Childrens Hosp, Qingdao, Shandong, Peoples R China; [Xing, Yuhan] Chinese Univ Hong Kong, Fac Med, Dept Paediat, Hong Kong, Peoples R China"

通信作者："Xing, YH (通讯作者)，Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Shenzhen 518107, Peoples R China.; Xing, YH (通讯作者)，Qingdao Univ, Qingdao Women & Childrens Hosp, Qingdao, Shandong, Peoples R China.; Xing, YH (通讯作者)，Chinese Univ Hong Kong, Fac Med, Dept Paediat, Hong Kong, Peoples R China."

来源：SLEEP AND BREATHING

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001173073400001

JCR分区：Q3

影响因子：2.1

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Obstructive sleep apnoea; Children; Allergic rhinitis; Risk factor

摘要："Purpose Obstructive sleep apnoea (OSA) is a common sleep-related breathing disorder affecting children. This study aims to characterize factors associated with the development and progression of severe forms of paediatric OSA. Methods This study included children admitted to Children's Hospital of Chongqing Medical University, a tertiary children's hospital in southwest China between January 2020 and December 2020 with a discharge diagnosis of OSA. Each patient underwent polysomnography examination, following assessments of apnoea-hypopnea index (AHI) and lowest oxygen saturation (LSaO2) by standardized techniques. Demographic and clinical information was collected from the hospital's electronic medical records. Associations between OSA severity and various factors were first examined in a univariate logistic model, with subsequent multivariate analysis to further identify independent risk factors. Results A total of 263 children were identified during the study period. Among patients presenting with OSA, 51.3% had mild and 48.7% had moderate to severe symptoms according to standardized guidelines. The incidence of mild and moderate to severe hypoxemia in our population was 39.2% and 60.8%, respectively. Allergic rhinitis (AR; adjusted odds ratio (aOR) = 1.75, 95% CI 1.03-2.96) and male gender (aOR = 1.77, 95% CI 1.03-3.06) were significantly associated with moderate-to-severe OSA (all P-values < 0.05) after adjustment for covariates. AR was also the only significant predictor of hypoxemia (P < 0.05). Conclusion Our results suggest that male gender and presence of AR may be associated with an increased likelihood of moderate-to-severe OSA in children. These findings underscore the importance of timely intervention and individualized management for at-risk individuals."

基金机构：National Natural Science Foundation of China [82300031]

基金资助正文：This study was supported by the National Natural Science Foundation of China (No. 82300031).