Causal effects of endometriosis on SLE, RA and SS risk: evidence from meta-analysis and Mendelian randomization

作者全名：Tang, Tianyou; Zhong, Yi; Xu, Sipei; Yu, Huilin

作者地址：[Tang, Tianyou; Zhong, Yi] Chongqing Med Univ, Childrens Hosp, Chongqing, Peoples R China; [Xu, Sipei] Chongqing Med Univ, Med Coll 1, Chongqing, Peoples R China; [Yu, Huilin] Chongqing Med Univ, Med Coll 2, Chongqing, Peoples R China

通信作者：Tang, TY (通讯作者)，Chongqing Med Univ, Childrens Hosp, Chongqing, Peoples R China.

来源：BMC PREGNANCY AND CHILDBIRTH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001173073900006

JCR分区：Q1

影响因子：2.8

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Endometriosis; Systemic lupus erythematosus (SLE); Rheumatoid arthritis (RA); Sjogren's syndrome (SS); Meta-analysis; Mendelian randomization

摘要：BackgroundEndometriosis is an underdiagnosed disorder that affects an estimated 6-10% of women of reproductive age. Endometriosis has been reported in epidemiological studies to be associated with autoimmune diseases. However, the relationship remains controversial.MethodsA meta-analysis of observational studies was undertaken to evaluate the risk of autoimmune diseases in patients with endometriosis. The relevant studies were retrieved via the databases Medline, Embase and Web of Science until July 20, 2023. Mendelian randomization (MR) was subsequently utilized to scrutinize the causal influence of genetic predisposition toward endometriosis on three autoimmune diseases.ResultsThe meta-analysis findings revealed a relationship between endometriosis and the onset of SLE (cohort studies: RR = 1.77, 95% confidence interval (CI): 1.47-2.13, I2 = 0%; Case-control and cross-sectional studies: OR = 5.23, 95% CI: 0.74-36.98, I2 = 98%), RA (cohort studies: RR = 2.18, 95% CI: 1.85-2.55, I2 = 92%; Case-control and cross-sectional studies: OR = 1.40, 95% CI: 1.19-1.64, I2 = 0%) and SS (cohort studies: RR = 1.49, 95% CI: 1.34-1.66, I2 = 0%). Similarly, in our MR study, the results of the inverse-variance-weighted (IVW) model suggested that genetic predisposition to endometriosis was causally associated with an increased risk for SLE (OR = 1.915, 95% CI: 1.204-3.045, p = 0.006) and RA (OR = 1.005, 95% CI: 1.001-1.009, p = 0.014).ConclusionsBoth our meta-analysis and MR study indicate that endometriosis increases the risk of autoimmune diseases. These findings not only broaden our understanding of the genetic mechanisms underlying the comorbidity of endometriosis and autoimmune diseases, but also offer a new strategy for autoimmune disease prevention.

基金机构：National innovation and entrepreneurship training program [SRIEP202104]

基金资助正文：This work was supported by National innovation and entrepreneurship training program [SRIEP202104].