Effectiveness of APG and Honey Gauze in Pressure Injury of Elderly: A Randomized Control Trial

作者全名："Xu, Lulu; Wang, Xinmeng; Wu, Yongmei; Zhang, Zhen; Li, Xiafei; Zhang, Jie"

作者地址："[Xu, Lulu; Wu, Yongmei; Li, Xiafei; Zhang, Jie] Chongqing Gen Hosp, Chongqing Clin Res Ctr Geriatr Dis, Dept Geriatr, Chongqing, Peoples R China; [Wang, Xinmeng] Chongqing Med Univ, Chinese Acad Sci, Chongqing, Peoples R China; [Wang, Xinmeng] Chongqing Inst Green & Intelligent Technol, Chongqing, Peoples R China; [Wang, Xinmeng] Univ Chinese Acad Sci, Chongqing Sch, Chongqing, Peoples R China; [Zhang, Zhen] Chongqing Gen Hosp, Dept Clin Lab, Chongqing, Peoples R China; [Zhang, Jie] Chongqing Med Univ, Grad Sch, Chongqing, Peoples R China; [Li, Xiafei] Chongqing Gen Hosp, Chongqing Clin Res Ctr Geriatr Dis, Dept Geriatr, 118 Xingguang Ave,Liangjiang New Area, Chongqing 401147, Peoples R China; [Zhang, Jie] Chongqing Med Univ, Grad Sch, 118 Xingguang Ave,Liangjiang New Area, Chongqing 401147, Peoples R China; [Zhang, Jie] Chongqing Gen Hosp, Dept Geriatr, 118 Xingguang Ave,Liangjiang New Area, Chongqing 401147, Peoples R China; [Zhang, Jie] Chongqing Gen Hosp, Chongqing Clin Res Ctr Geriatr Dis, 118 Xingguang Ave,Liangjiang New Area, Chongqing 401147, Peoples R China"

通信作者："Li, XF (通讯作者)，Chongqing Gen Hosp, Chongqing Clin Res Ctr Geriatr Dis, Dept Geriatr, 118 Xingguang Ave,Liangjiang New Area, Chongqing 401147, Peoples R China.; Zhang, J (通讯作者)，Chongqing Med Univ, Grad Sch, 118 Xingguang Ave,Liangjiang New Area, Chongqing 401147, Peoples R China.; Zhang, J (通讯作者)，Chongqing Gen Hosp, Dept Geriatr, 118 Xingguang Ave,Liangjiang New Area, Chongqing 401147, Peoples R China.; Zhang, J (通讯作者)，Chongqing Gen Hosp, Chongqing Clin Res Ctr Geriatr Dis, 118 Xingguang Ave,Liangjiang New Area, Chongqing 401147, Peoples R China."

来源：INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001173191800001

JCR分区：Q3

影响因子：1.5

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：honey; platelet-rich plasma; pressure ulcer; wound healing

摘要："This study was designed to evaluate the efficiency of the combination of autologous platelet-rich plasma gel (APG) and Manuka honey gauze in the treatment of Stages 3-4 pressure injury of older adults. Patients were divided into four groups: Manuka honey gauze and APG (M + A), Manuka honey gauze (M), APG (A), and a control group (C). Different treatments were given, then wound bed coverage with granulation tissue, wound size reduction, and Pressure Ulcer Scale for Healing (PUSH) score were examined. Paraffin-embedded sections of wound tissues were analyzed and wound swab cultures were assessed. Kruskal-Wallis test and Mann-Whitney U test were performed in statistical analysis at a 5% significance level. A total of 42 patients were accepted. Significant increase of wound bed coverage with granulation tissue (51.24%, P = .004, Kruskal-Wallis test) and decrease of PUSH score (-5) were observed in the M + A group at the end of the observation (P = .032, Mann-Whitney U test). The hematoxylin-eosin staining of wound tissues showed that typical squamous epithelium was seen in wound bed of patient in M + A group. Manuka honey gauze and APG were proved to be superior treatments for pressure injury of old patient. Increase of granulation tissue coverage, reduction of PUSH score, and improved growth of epithelium were observed in M + A group. There was no side-effect, and the treatment would not cause infection."

基金机构：Medical Technology Innovation Fund Project of Chongqing General Hospital [Y2017MSXM01]; Joint Medical Research Project of Science and Technology Committee and Health and Family Planning Commission of Chongqing [2020FYYX037]; Chongqing Yu Zhong District Science and Technology Plan Project [20170416]; Chongqing Natural Science Foundation [cstc2021jcyj-msxmX1129]

基金资助正文：This work was supported by the Medical Technology Innovation Fund Project of Chongqing General Hospital (grant number Y2017MSXM01). The Joint Medical Research Project of Science and Technology Committee and Health and Family Planning Commission of Chongqing (grant number 2020FYYX037). Chongqing Yu Zhong District Science and Technology Plan Project (grant number 20170416) and Chongqing Natural Science Foundation (grant number cstc2021jcyj-msxmX1129)