"Acupoint Therapy with Injectable, Pro-Healing Stem Cell-Loaded Hydrogel Microspheres Promotes Skin Wound Healing"

作者全名："Yan, Yinqiu; Chen, Liling; Zheng, Liwen; Wang, Gen; Zhang, Hongmei; Feng, Xing; Liu, Yaxian; Li, Lan; Zhang, Yu Shrike; Ji, Ping; Zhang, Ximu"

作者地址："[Yan, Yinqiu; Chen, Liling; Zheng, Liwen; Zhang, Hongmei; Feng, Xing; Liu, Yaxian; Li, Lan; Ji, Ping; Zhang, Ximu] Chongqing Med Univ, Stomatol Hosp, Chongqing 401147, Peoples R China; [Wang, Gen] Chongqing Hosp Tradit Chinese Med, Dept Rehabil, Chongqing 400021, Peoples R China; [Zhang, Yu Shrike] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Cambidge, MA 02139 USA"

通信作者："Ji, P; Zhang, XM (通讯作者)，Chongqing Med Univ, Stomatol Hosp, Chongqing 401147, Peoples R China.; Zhang, YS (通讯作者)，Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Cambidge, MA 02139 USA."

来源：ADVANCED FUNCTIONAL MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001173651800001

JCR分区：Q1

影响因子：19

年份：2024

卷号：34

期号：26

开始页：　

结束页：　

文献类型：Article

关键词：acupuncture; microspheres; multi-omics; stem cells; wound healing; Yin-Yang

摘要："Wound repair is a complex and dynamic process, involving stages of hemostasis, inflammation, proliferation, and remodeling. Standard methods currently used for clinical treatment of skin defects remain unsatisfying and alternative treatments have emerged including acupuncture mostly relying on the conventional needle method. It is applied sustained acupuncture therapy with bioengineered stem cell-loaded hydrogel microspheres (A-SGC), where the data gathered through transcriptomics, metabolomics, and single-cell omics analyses are used to construct a comprehensive multi-omics map underlying the wound regeneration process with such a therapy. Under the treatment of A-SGC, the interactions and Yin-Yang balance among fibroblasts, macrophages, endothelial cells, and keratinocytes facilitated skin regeneration instead of scarred healing. The genes related to the promotion of matrix synthesis and re-epithelialization played important roles in the transition from the inflammatory granulation phase to the stromal remodeling phase. This convergence use of hydrogel microspheres, stem cells, and sustained acupuncture therapy could have previously unattainable therapeutic implications for improved wound treatment. Sustained acupuncture therapy is applied with bioengineered stem cell-loaded hydrogel microspheres, where the interactions and Yin-Yang balance among fibroblasts, macrophages, endothelial cells, and keratinocytes facilitated skin regeneration instead of scarred healing. This convergence use of hydrogel microspheres, stem cells, and sustained acupuncture therapy is anticipated to have previously unattainable therapeutic implications for improved wound treatment. image"

基金机构：National Natural Science Foundation of China; Chongqing Science and Health Joint Medical project [2020GDRC017]; Outstanding Youth Fund of Chongqing Natural Science Foundation [CSTB2023NSCQ-JQX0006]; Science and Technology Research Project of Chongqing Education Commission [KJQN202200471]; Brigham Research Institute; [32070826]

基金资助正文："Y.Y., L.C., and L.Z. contributed equally to this work. This work was financed by the National Natural Science Foundation of China (32070826), Chongqing Science and Health Joint Medical project (2020GDRC017), Outstanding Youth Fund of Chongqing Natural Science Foundation (CSTB2023NSCQ-JQX0006), Science and Technology Research Project of Chongqing Education Commission (KJQN202200471). Y.S.Z. was not supported by any of these funds; instead, support by the Brigham Research Institute is acknowledged."