"Iron-Catalyzed [2+1+2+1] Annulation of Amines and <i>N</i> , <i>N</i> -Dimethyl Enaminones using <i>N</i> , <i>N</i> -Dimethylaminoethanol as a One-Carbon Synthon for the Synthesis of 1,4-Dihydropyridines"
作者全名："Ma, Wanqian; Kuang, Qiulin; Li, Suzhen; Guo, Mengyi; Song, Yibo; Cheng, Luoteng; Yuan, Jianyong"
作者地址："[Ma, Wanqian; Kuang, Qiulin; Li, Suzhen; Guo, Mengyi; Song, Yibo; Cheng, Luoteng; Yuan, Jianyong] Chongqing Med Univ, Dept Med Chem, Coll Pharm, Chongqing 400016, Peoples R China"
通信作者："Yuan, JY (通讯作者)，Chongqing Med Univ, Dept Med Chem, Coll Pharm, Chongqing 400016, Peoples R China."
来源：SYNTHESIS-STUTTGART
ESI学科分类：CHEMISTRY
WOS号：WOS:001174355100002
JCR分区：Q2
影响因子：2.2
年份：2024
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文献类型：Article; Early Access
关键词："1,4-dihydropyridines; N , N -dimethylaminoethanol; annulation; multi-component reactions; iron catalysis"
摘要："A simple and efficient method for the synthesis of 1,4-dihy-dropyridines from amines, N,N-dimethyl enaminone and N,N-dimethyl-aminoethanol in a four-component [2+1+2+1] annulation catalyzed byFeCl3 has been established, where N,N-dimethylaminoethanol was applied as a methine source. The procedure was executed smoothly, resulting in the synthesis of a wide range of 1,4-dihydropyridines withmoderate to good yields. Additionally, these fluorophores exhibited good photophysical characteristics."
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