Metabolomics study reveals blood biomarkers for early diagnosis of chronic kidney disease and IgA nephropathy: A retrospective cross-sectional study

作者全名："Fu, Xian; Luo, Zhi-Xiao; Yin, Hou-Hua; Liu, Ya-Nan; Du, Xiao-Gang; Cheng, Wei; Liu, Jun-Yan"

作者地址："[Fu, Xian; Yin, Hou-Hua; Liu, Ya-Nan; Liu, Jun-Yan] Chongqing Med Univ, CNTTI Inst Life Sci, Chongqing 400016, Peoples R China; [Fu, Xian; Yin, Hou-Hua; Liu, Ya-Nan; Liu, Jun-Yan] Chongqing Med Univ, Affiliated Hosp 2, Anesthesia Dept, Chongqing 400016, Peoples R China; [Fu, Xian; Yin, Hou-Hua; Liu, Ya-Nan; Liu, Jun-Yan] Minist Educ, Basic Med Res & Innovat Ctr Novel Target & Therape, Chongqing 400016, Peoples R China; [Fu, Xian; Liu, Jun-Yan] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China; [Luo, Zhi-Xiao; Cheng, Wei] Chongqing Med Univ, Ctr Clin Mol Med Detect, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Du, Xiao-Gang] Chongqing Med Univ, Dept Nephrol, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Liu, JY (通讯作者)，Chongqing Med Univ, CNTTI Inst Life Sci, Chongqing 400016, Peoples R China.; Liu, JY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Anesthesia Dept, Chongqing 400016, Peoples R China.; Cheng, W (通讯作者)，Chongqing Med Univ, Ctr Clin Mol Med Detect, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Du, XG (通讯作者)，Chongqing Med Univ, Dept Nephrol, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：CLINICA CHIMICA ACTA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001174770700001

JCR分区：Q2

影响因子：3.2

年份：2024

卷号：555

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Chronic kidney disease; Early diagnosis; IgA nephropathy; Indole-3-lactic acid; Melatonin; Tryptophan metabolism

摘要："Background and aims: Chronic kidney disease (CKD) causes low quality of life and alarming morbidity and mortality. The crucial to retard CKD progression is to diagnose early for timely treatment. IgA nephropathy (IgAN) is a typical CKD and the most common glomerulonephritis. Both CKD and IgAN lack accurate and sensitive blood biomarkers for early diagnosis. Here we report the potential of plasma biomarkers for early diagnosis of CKD and IgAN. Materials and methods: Plasma levels of metabolites derived from tryptophan were quantified with an LC-MS/MSbased metabolomics for two cohorts. Based on the predictive probability of each metabolite, multivariate models including logistic regression and random forest were used to establish the early diagnostic biomarkers for CKD and IgAN. Results: The plasma melatonin diagnosed early CKD (stages I-II) with an accuracy exceeding 95%, and a panel of melatonin and tryptophan achieved a remarkable 100% accuracy in diagnosing early CKD. Furthermore, indole3-lactic acid had an excellent ability to distinguish IgAN among CKD patients. Based on the CKD screening and IgAN diagnosis primarily contributed by melatonin and indole-3-lactic acid, early IgAN could be diagnosed with an accuracy of over 85%. Conclusions: This study provides promising plasma biomarkers for early diagnosis of CKD and IgAN."

基金机构：National key projects of the Ministry of Science and Technology of China [2022YFE0131300]; National Natural Science Foundation of China [82273408]; Chongqing Municipal Natural Science Foundation -Education Commission Joint Fund for Innovation and Development Key Project [CSTB2022NSCQ- LZX0027]; Chongqing Education Committee University Inno- vation Research Group Grant [CXQT21016]

基金资助正文："This work was co -supported by the National key projects of the Ministry of Science and Technology of China (2022YFE0131300) , the National Natural Science Foundation of China (82273408) , Chongqing Municipal Natural Science Foundation -Education Commission Joint Fund for Innovation and Development Key Project (CSTB2022NSCQ- LZX0027) , and the Chongqing Education Committee University Inno- vation Research Group Grant (CXQT21016) . The authors would like to thank all the patients and healthy volunteers for their participation in this study and the nurses and technical staff for helping with sample collection and storage."