Lipotoxicity: The missing link between diabetes and periodontitis?

作者全名："Sun, Yu; Yin, Yuanyuan; Yang, Sihan; Ai, Dongqing; Qin, Han; Xia, Xuyun; Xu, Xiaohui; Song, Jinlin"

作者地址："[Sun, Yu; Yin, Yuanyuan; Yang, Sihan; Ai, Dongqing; Qin, Han; Xu, Xiaohui; Song, Jinlin] Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China; [Sun, Yu; Yin, Yuanyuan; Yang, Sihan; Ai, Dongqing; Qin, Han; Xu, Xiaohui; Song, Jinlin] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China; [Sun, Yu; Yin, Yuanyuan; Yang, Sihan; Ai, Dongqing; Qin, Han; Xu, Xiaohui; Song, Jinlin] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China; [Xia, Xuyun] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing, Peoples R China; [Xu, Xiaohui; Song, Jinlin] Chongqing Med Univ, Coll Stomatol, 426 Songshibei Rd, Chongqing 401147, Peoples R China"

通信作者："Xu, XH; Song, JL (通讯作者)，Chongqing Med Univ, Coll Stomatol, 426 Songshibei Rd, Chongqing 401147, Peoples R China."

来源：JOURNAL OF PERIODONTAL RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001175008100001

JCR分区：Q1

影响因子：3.4

年份：2024

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期号：　

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文献类型：Review; Early Access

关键词：apoptosis; diabetes mellitus; fatty acids; oxidative stress; pathology; type 2

摘要："Lipotoxicity refers to the accumulation of lipids in tissues other than adipose tissue (body fat). It is one of the major pathophysiological mechanisms responsible for the progression of diabetes complications such as non-alcoholic fatty liver disease and diabetic nephropathy. Accumulating evidence indicates that lipotoxicity also contributes significantly to the toxic effects of diabetes on periodontitis. Therefore, we reviewed the current in vivo, in vitro, and clinical evidence of the detrimental effects of lipotoxicity on periodontitis, focusing on its molecular mechanisms, especially oxidative and endoplasmic reticulum stress, inflammation, ceramides, adipokines, and programmed cell death pathways. By elucidating potential therapeutic strategies targeting lipotoxicity and describing their associated mechanisms and clinical outcomes, including metformin, statins, liraglutide, adiponectin, and omega-3 PUFA, this review seeks to provide a more comprehensive and effective treatment framework against diabetes-associated periodontitis. Furthermore, the challenges and future research directions are proposed, aiming to contribute to a more profound understanding of the impact of lipotoxicity on periodontitis."

基金机构："National Key R&D of Program of China; National Natural Science Foundation of China [82101014, 81771082, 31971282, U22A20314]; Natural Science Foundation of Chongqing [cstc2021jcyj-bsh0005]; Chongqing Graduate Tutor Team; China Postdoctoral Science Foundation [2021M700628]; [2022YFC2504200]"

基金资助正文："This work was financially supported by funding from the National Key R&D of Program of China (Grant No. 2022YFC2504200), National Natural Science Foundation of China (Grant Nos. 82101014, 81771082, 31971282, U22A20314), Natural Science Foundation of Chongqing (Grant No. cstc2021jcyj-bsh0005), the Chongqing Graduate Tutor Team (2019) (Grant No. dstd201903) and China Postdoctoral Science Foundation (Grant No. 2021M700628)."