Multifunctional Prosthesis Surface: Modification of Titanium with Cinnamaldehyde-Loaded Hierarchical Titanium Dioxide Nanotubes

作者全名："Mao, Yi; Xie, Xinru; Sun, Guangxin; Yu, Shiqi; Ma, Mingqi; Chao, Rui; Wan, Tianhao; Xu, Weifeng; Chen, Xuzhuo; Sun, Lei; Zhang, Shanyong"

作者地址："[Mao, Yi; Xie, Xinru; Ma, Mingqi; Chao, Rui; Wan, Tianhao; Xu, Weifeng; Chen, Xuzhuo; Sun, Lei; Zhang, Shanyong] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Coll Stomatol, Natl Ctr Stomatol,Dept Oral Surg,Sch Med,Shanghai, Shanghai, Peoples R China; [Sun, Guangxin] China Med Univ Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Shenyang 110002, Liaoning, Peoples R China; [Yu, Shiqi] Chongqing Med Univ, Dept Nursing, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Sun, Lei] Anhui Med Univ, Dept Stomatol, Affiliated Hosp 2, Hefei 230601, Anhui, Peoples R China"

通信作者："Chen, XZ; Sun, L; Zhang, SY (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Coll Stomatol, Natl Ctr Stomatol,Dept Oral Surg,Sch Med,Shanghai, Shanghai, Peoples R China.; Sun, L (通讯作者)，Anhui Med Univ, Dept Stomatol, Affiliated Hosp 2, Hefei 230601, Anhui, Peoples R China."

来源：ADVANCED HEALTHCARE MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001175040000001

JCR分区：Q1

影响因子：10

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：anti-inflammatory materials; antibacterials; bone osseointegration; osteoclastogenesis; titanium implants

摘要："Orthopedic prostheses are the ultimate therapeutic solution for various end-stage orthopedic conditions. However, aseptic loosening and pyogenic infections remain as primary complications associated with these devices. In this study, a hierarchical titanium dioxide (TiO2) nanotube drug delivery system loaded with cinnamaldehyde for the surface modification of titanium implants, is constructed. These specially designed dual-layer TiO2 nanotubes enhance material reactivity and provide an extensive drug-loading platform within a short time. The introduction of cinnamaldehyde enhances the bone integration performance of the scaffold (simultaneously promoting bone formation and inhibiting bone resorption), anti-inflammatory capacity, and antibacterial properties. In vitro experiments have demonstrated that this system promoted osteogenesis by upregulating both Wnt/beta-catenin and MAPK signaling pathways. Furthermore, it inhibits osteoclast formation, suppresses macrophage-mediated inflammatory responses, and impedes the proliferation of Staphylococcus aureus and Escherichia coli. In vivo experiments shows that this material enhances bone integration in a rat model of femoral defects. In addition, it effectively enhances the antibacterial and anti-inflammatory properties in a subcutaneous implant in a rat model. This study provides a straightforward and highly effective surface modification strategy for orthopedic Ti implants. A dual-layered nanotube structure of titanium dioxide (TiO2) loaded with cinnamaldehyde promotes bone integration, anti-inflammation, and antibacterial properties in surface modification of titanium metal. image"

基金机构：Program of Shanghai Academic/Technology Research Leader; Anhui Provincial Natural Science Foundation [2308085MH264]; China Postdoctoral Science Foundation [2023M732284]; Scientific Research Project of Anhui Provincial Health Commission [GAHWJ2021b108]; Open Project of Translational Medicine National Science and Technology Infrastructure (Shanghai) [TMSK-2021-143]; Research Fund of the Anhui Institute of Translational Medicine [2021zhyx-C44]; Shanghai Sailing Program [21YF1423600]; [21XD1431500]

基金资助正文："This work was supported by the Program of Shanghai Academic/Technology Research Leader (No.: 21XD1431500), Anhui Provincial Natural Science Foundation (No.: 2308085MH264), China Postdoctoral Science Foundation (No.: 2023M732284), and the Scientific Research Project of Anhui Provincial Health Commission (No.: GAHWJ2021b108), Open Project of Translational Medicine National Science and Technology Infrastructure (Shanghai) (No.: TMSK-2021-143), and the Research Fund of the Anhui Institute of Translational Medicine (No.: 2021zhyx-C44), Sponsored by Shanghai Sailing Program (21YF1423600)."