Pulse pressure variation guided goal-direct fluid therapy decreases postoperative complications in elderly patients undergoing laparoscopic radical resection of colorectal cancer: a randomized controlled trial

作者全名："Wu, Qiu-Rong; Zhao, Zi-Zuo; Fan, Ke-Ming; Cheng, Hui-Ting; Wang, Bin"

作者地址："[Wu, Qiu-Rong; Zhao, Zi-Zuo; Cheng, Hui-Ting; Wang, Bin] Chongqing Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Fan, Ke-Ming] Yongchuan Dist Peoples Hosp Chongqing, Dept Anesthesiol, Chongqing 400016, Peoples R China"

通信作者："Wang, B (通讯作者)，Chongqing Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001175461100001

JCR分区：Q1

影响因子：2.5

年份：2024

卷号：39

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：PPV; Goal-directed fluid therapy; Laparoscopic; Elderly; Radical resection of colorectal cancer; Complications

摘要："ObjectiveThe use of goal-directed fluid therapy (GDFT) has been shown to reduce complications and improve prognosis in high-risk abdominal surgery patients. However, the utilization of pulse pressure variation (PPV) guided GDFT in laparoscopic surgery remains a subject of debate. We hypothesized that utilizing PPV guidance for GDFT would optimize short-term prognosis in elderly patients undergoing laparoscopic radical resection for colorectal cancer compared to conventional fluid therapy.MethodsElderly patients undergoing laparoscopic radical resection of colorectal cancer were randomized to receive either PPV guided GDFT or conventional fluid therapy and explore whether PPV guided GDFT can optimize the short-term prognosis of elderly patients undergoing laparoscopic radical resection of colorectal cancer compared with conventional fluid therapy.ResultsThe incidence of complications was significantly lower in the PPV group compared to the control group (32.8% vs. 57.1%, P = .009). Additionally, the PPV group had a lower occurrence of gastrointestinal dysfunction (19.0% vs. 39.3%, P = .017) and postoperative pneumonia (8.6% vs. 23.2%, P = .033) than the control group.ConclusionUtilizing PPV as a monitoring index for GDFT can improve short-term prognosis in elderly patients undergoing laparoscopic radical resection of colorectal cancer.Registration numberChiCTR2300067361; date of registration: January 5, 2023."

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