Image-defined risk factors associated with<i> MYCN</i> oncogene amplification in neuroblastoma and their association with overall survival

作者全名："Wang, Haoru; Li, Ting; Ni, Xiaoying; Chen, Xin; He, Ling; Cai, Jinhua"

作者地址："[Wang, Haoru; Li, Ting; Ni, Xiaoying; Chen, Xin; He, Ling; Cai, Jinhua] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Radiol,Minist Educ,Key Lab Child Dev & Disord, 136 Zhongshan Rd 2, Chongqing 400014, Peoples R China"

通信作者："Chen, X; He, L; Cai, JH (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Radiol,Minist Educ,Key Lab Child Dev & Disord, 136 Zhongshan Rd 2, Chongqing 400014, Peoples R China."

来源：ABDOMINAL RADIOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001175839300003

JCR分区：Q2

影响因子：2.4

年份：2024

卷号：49

期号：4

开始页：1320

结束页：1329

文献类型：Article

关键词：Children; Computed tomography; Image-defined risk factors; Magnetic resonance imaging; MYCN oncogene; Neuroblastoma

摘要："Objective The MYCN oncogene is a critical factor in the development and progression of neuroblastoma, and image-defined risk factors (IDRFs) are radiological findings used for the preoperative staging of neuroblastoma. This study aimed to investigate the specific categories of IDRFs associated with MYCN amplification in neuroblastoma and their association with overall survival. Method A retrospective analysis was conducted on a cohort of 280 pediatric patients diagnosed with neuroblastoma, utilizing a combination of clinical and radiological data. MYCN amplification status was ascertained through molecular testing, and the assessment of IDRFs was conducted using either contrast-enhanced computed tomography or magnetic resonance imaging. The specific categories of IDRFs associated with MYCN amplification and their association with overall survival were analyzed. Results MYCN amplification was identified in 19.6% (55/280) of patients, with the majority of primary lesions located in the abdomen (53/55, 96.4%). Lesions accompanied by MYCN amplification exhibited significantly larger tumor volume and a greater number of IDRFs compared with those without MYCN amplification (P < 0.001). Both univariate and multivariate analyses revealed that coeliac axis/superior mesenteric artery encasement and infiltration of adjacent organs/structures were independently associated with MYCN amplification in abdominal neuroblastoma (P < 0.05). Patients presenting with more than four IDRFs experienced a worse prognosis (P = 0.017), and infiltration of adjacent organs/structures independently correlated with overall survival in abdominal neuroblastoma (P = 0.009). Conclusion The IDRFs are closely correlated with the MYCN amplification status and overall survival in neuroblastoma."

基金机构：National Natural Science Foundation of Chongqing

基金资助正文：None.