Ultrasound Tissue Engineering Technology for Regulating Immune Microenvironment

作者全名："Li, Xinhe; Ding, Xiaoqian; He, Yi; Yi, Weiwei; Zhu, Ying; Han, Wang; Liao, Bo; Han, Xiaoyu; Bai, Dingqun"

作者地址："[Li, Xinhe; Ding, Xiaoqian; He, Yi; Yi, Weiwei; Zhu, Ying; Han, Wang; Liao, Bo; Han, Xiaoyu; Bai, Dingqun] Chongqing Med Univ, Affiliated Hosp 1, Dept Rehabil Med, Chongqing 400010, Peoples R China; [Bai, Dingqun] Chongqing Med Univ, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China"

通信作者："Han, XY; Bai, DQ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Rehabil Med, Chongqing 400010, Peoples R China.; Bai, DQ (通讯作者)，Chongqing Med Univ, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China."

来源：ADVANCED FUNCTIONAL MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001176837400001

JCR分区：Q1

影响因子：18.5

年份：2024

卷号：　

期号：　

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结束页：　

文献类型：Review; Early Access

关键词：immune microenvironment; ultrasound; ultrasound tissue engineering technology; ultrasound-responsive biomaterials

摘要："The immune microenvironment is critical for the occurrence, progression, and treatment of diseases. Ultrasound tissue engineering technology utilizes ultrasound and the principles of tissue engineering to repair, regenerate, and functionally reconstruct biological tissues. Ultrasound therapy is a non-invasive treatment modality that regulates the immune microenvironment and maintains homeostasis through various characteristic effects. Ultrasound-responsive biomaterials utilize biological properties or drug/gene delivery to regulate the immune microenvironment under ultrasound stimulation for targeted and purposeful treatment. This article comprehensively and systematically reviews advancements in ultrasound tissue engineering technology for regulating the immune microenvironment. First, the changes in the immune microenvironment at different stages of the disease is briefly illustrated. It is then reviewed the regulation of the immune microenvironment by ultrasound and ultrasound-responsive biomaterials in five types of diseases: tumor, cardiovascular system diseases, nervous system diseases, musculoskeletal diseases, and wound. Finally, the prospects of the ultrasound tissue engineering technology for regulating the immune microenvironment is summarized. Ultrasound tissue engineering technology is widely used in various diseases including tumor, cardiovascular system diseases, nervous system diseases, musculoskeletal diseases, and wound. Ultrasound and ultrasound-responsive biomaterials utilize the characteristics of ultrasound and biomaterial properties or drug/gene delivery to regulate the immune microenvironment for targeted treatment, which is a promising strategy for tissue repair, regeneration, and functional reconstruction. image"

基金机构："National Natural Science Foundation of China [82372572, 82172533]; Chongqing Natural Science Foundation Innovation and Development Joint Fund (key point) [CSTB2023NSCQ-LZX006]; Chongqing Science and Health Joint Medical Research Key Project [2024ZDXM005]; Natural Science Basic Research Program of Shaanxi [2024JC-YBQN-0877]; Science and Technology Innovation Action Plan Domestic Science and Technology Cooperation Project of Shanghai; [23015820800]"

基金资助正文："X.L., X.D., and Y.H. contributed equally to this work. This work was supported in part by the National Natural Science Foundation of China (Nos. 82372572 and 82172533), Chongqing Natural Science Foundation Innovation and Development Joint Fund (key point) (No. CSTB2023NSCQ-LZX006), Chongqing Science and Health Joint Medical Research Key Project (No. 2024ZDXM005), Natural Science Basic Research Program of Shaanxi (Program No.2024JC-YBQN-0877). ""Science and Technology Innovation Action Plan"" Domestic Science and Technology Cooperation Project of Shanghai (2023) (No. 23015820800)."