Assessing the causal relationship between COVID-19 and post-COVID-19 syndrome: A Mendelian randomisation study

作者全名："Tao, Yiming; Zhao, Rui; Han, Jie; Li, Yongsheng"

作者地址："[Tao, Yiming; Li, Yongsheng] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Intens Care Med, Tongji Med Coll, 1095 Jiefang Ave, Wuhan 430030, Peoples R China; [Zhao, Rui] Chongqing Med Univ, Dept Lab Med, Affiliated Hosp 1, Chongqing, Peoples R China; [Han, Jie] Qingdao Univ, Sch Med, Qingdao Municipal Hosp, Dept Emergency, 5 Donghai Middle Rd, Qingdao 266071, Peoples R China"

通信作者："Li, YS (通讯作者)，Huazhong Univ Sci & Technol, Tongji Hosp, Dept Intens Care Med, Tongji Med Coll, 1095 Jiefang Ave, Wuhan 430030, Peoples R China.; Han, J (通讯作者)，Qingdao Univ, Sch Med, Qingdao Municipal Hosp, Dept Emergency, 5 Donghai Middle Rd, Qingdao 266071, Peoples R China."

来源：JOURNAL OF GLOBAL HEALTH

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:001177723300003

JCR分区：Q1

影响因子：4.5

年份：2023

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Background In the aftermath of the coronavirus disease 2019 (COVID-19) pandemic, we sought to explore the causal association between COVID-19 and 17 prevalent post-COVID-19 syndrome (PCS) symptoms using Mendelian randomisation (MR) methodology. Methods We used 22 extensive genome-wide association study (GWAS) data sets, incorporating genetic variants as instrumental variables. Univariate Mendelian randomisation (UVMR) analyses involved 15 single nucleotide polymorphisms (SNPs) for COVID-19 patients, 33 for hospitalised COVID-19 patients, and 29 for patients with severe respiratory symptoms due to COVID-19. Furthermore, we further used multivariable Mendelian randomisation (MVMR) analyses based on 93 SNPs for COVID-19 patients, 105 for hospitalised COVID-19 patients, and 99 for patients with severe respiratory symptoms due to COVID-19. With these analyses, we aimed to assess the causal associations between varying levels of COVID-19 infection and 17 prevalent PCS symptoms while accounting for the influence of educational and income levels. Results UVMR analysis identified potential causal effects of COVID-19 genetic susceptibility on myalgia and pain in various regions. Hospitalised COVID-19 was potentially linked to erectile dysfunction and alopecia areata. Very severe respiratory confirmed patients exhibited increased pain and tobacco use. Meanwhile, the MVMR analysis demonstrated a potential causal link between hospitalised COVID-19 and heart arrhythmia, and a protective effect of COVID-19 on tobacco use after adjusting for educational and income levels. Conclusions Our MR analysis provides compelling evidence of causal associations between genetic susceptibility to COVID-19 and specific PCS symptoms, in which educational and income levels play a mediating role. These findings shed light on PCS pathogenesis and underscore the importance of considering social factors in its management. Tailored interventions and policies are crucial for PCS-affected individuals' well-being. Further research is needed to explore the impact of social determinants on COVID-19 patients and the wider population."

基金机构：Beijing Medical and Health Foundation [YWJKJJHKYJJ-BXS5-22001]

基金资助正文：The research was funded by grants from the Beijing Medical and Health Foundation (YWJKJJHKYJJ-BXS5-22001)