Sigmoidal relationship between liver fat content and nonalcoholic fatty liver disease in Chinese adults

作者全名："Yu, Pingping; Yang, Huachao; Li, Hu; Mei, Ying; Wu, Yuanyuan; Cheng, Hongfeng; Su, Huiru; Deng, Yueling; Jiang, Tao; He, Zhongxiang; Hu, Peng"

作者地址："[Yu, Pingping; Mei, Ying; Wu, Yuanyuan; Cheng, Hongfeng; Su, Huiru; Deng, Yueling; Jiang, Tao; He, Zhongxiang] Chongqing Med Univ, Affiliated Hosp 2, Hlth Med Ctr, Chongqing 400010, Peoples R China; [Yu, Pingping; Li, Hu; Hu, Peng] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Chinese Minist Educ,Key Lab Mol Biol Infect Dis,De, 288 Tianwen Ave, Chongqing 400010, Peoples R China; [Yang, Huachao] Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing 400010, Peoples R China"

通信作者："Hu, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Chinese Minist Educ,Key Lab Mol Biol Infect Dis,De, 288 Tianwen Ave, Chongqing 400010, Peoples R China."

来源：POSTGRADUATE MEDICAL JOURNAL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001177974500001

JCR分区：Q1

影响因子：3.6

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：nonalcoholic fatty liver disease; quantitative computed tomography; liver fat content

摘要："Purpose To explore the relationship between liver fat content (LFC) and nonalcoholic fatty liver disease (NAFLD) and determine the new threshold of LFC to diagnose NAFLD.Methods The data from questionnaire survey, general physical examination, laboratory examination, and image examination were collected. Multivariate regression analysis, receiver operating characteristic curve analysis, smooth curve fitting, and threshold effect analysis were performed using the R software to investigate the relationship between LFC and NAFLD and to identify the new threshold of LFC to diagnose NAFLD.Results The prevalence of NAFLD was 30.42%, with a significantly higher prevalence in men than in women. Regression analyses demonstrated that LFC odds ratio [95% confidence interval (CI)] was 1.28 (95% CI: 1.24-1.31) in fully-adjust model. Analysis of the LFC quartile, with Q1 as a reference, revealed that the odds ratios of NAFLD were 1.47 (95% CI: 1.08-1.99), 2.29 (95% CI: 1.72-3.06), and 10.02 (95% CI: 7.45-13.47) for Q2, Q3, and Q4 groups, respectively. Smooth curve fitting and threshold effect analysis displayed a nonlinear relationship between LFC and NAFLD, and the threshold was 4.5%. The receiver operating characteristic curve indicated that when LFC was 4.5%, the area under curve (95% CI) was 0.80 (0.79-0.82), and the sensitivity and specificity of LFC in diagnosing NAFLD were 0.64% and 0.82%, respectively.Conclusion The relationship between LFC and NAFLD was sigmoidal, with an inflection point of 4.5%. What is already known on this topic At present, there is no standard and uniform threshold for QCT diagnosis of hepatic steatosis, and its threshold is based on MRI. Therefore, this study aimed to explore the correlation between LFC and NAFLD and establish a novel threshold of LFC to diagnose NAFLD. What this study adds This is the first study to report a sigmoidal relationship between LFC and NAFLD with a threshold effect. When LFC was higher than 4.5%, the risk of NAFLD was significantly increased. LFC can be quantified by QCT, which can be a valuable tool for evaluating the NAFLD risk. How this study might affect research, practice, or policy The results of this study have important implications for research, practice, and policy. QCT can be utilized as a noninvasive technique for quantitatively assessing hepatic steatosis, providing a valuable reference for screening, diagnosing, and evaluating the treatment effect of NAFLD."

基金机构：Chongqing Talents Project [cstc2021ycjh-bgzxm0150]; Chongqing Science and Technology Commission Joint Medical Project [2021MSXM057]

基金资助正文："This work is supported by the Chongqing Talents Project [cstc2021ycjh-bgzxm0150], the Chongqing Science and Technology Commission Joint Medical Project [2021MSXM057]."