Physical activity can reduce the risk of blood cadmium and blood lead on stroke: Evidence from NHANES

作者全名："Deng, Xiaoqi; Liu, Dichuan; Li, Miao; He, Jie; Fu, Yufan"

作者地址："[Deng, Xiaoqi; Liu, Dichuan; He, Jie; Fu, Yufan] Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Li, Miao] Capital Med Univ, Beijing Tiantan Hosp, Beijing 100070, Peoples R China"

通信作者："Liu, DC (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China."

来源：TOXICOLOGY AND APPLIED PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001178183300001

JCR分区：Q2

影响因子：3.3

年份：2024

卷号：483

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Cadmium; Lead; Stroke; Physical Activity; NHANES

摘要："The detrimental impact of heavy metals on cardiovascular well-being is a global concern, and engaging in suitable physical activity has been shown to confer cardiovascular advantage. Nevertheless, the potential of exercise to mitigate the deleterious effects of heavy metals on stroke remains uncertain. We conducted a crosssectional survey to assess the influence of blood cadmium and blood lead on stroke occurrence, while also examining the role of physical activity. Weighted multivariate regression analysis was employed to examine the potential correlation, while subgroup and interaction analyses were used to investigate the sensitivity and robustness of the results. After controlling risk factors, it revealed a positive correlation between blood cadmium and lead levels and the occurrence of stroke. Specifically, a 50% increase in blood cadmium was associated with a 28% increase in stroke incidence, while a 50% increase in blood lead was associated with a 47% increase in stroke incidence. To estimate the non -linear relationship, we employed restricted cubic models. The results demonstrate a gradual decrease in the slope of the model curve as the intensity of physical activity increases, implying that engaging in physical activity may contribute to a reduction in the occurrence of stroke caused by blood cadmium and lead. Our findings suggest that blood cadmium and lead could be considered an autonomous risk factor for stroke within the general population of the United States. Moreover, engaging in physical activity has the potential to mitigate the potential detrimental consequences associated with exposure to heavy metals."

基金机构：National Natural Science Foundation of China [30670870]

基金资助正文：<B>Funding</B> This work was supported by the National Natural Science Foundation of China [grant numbers 30670870] .