Protective effects of docosahexaenoic acid supplementation on cognitive dysfunction and hippocampal synaptic plasticity impairment induced by early postnatal PM2.5 exposure in young rats

作者全名："Gui, Jianxiong; Xie, Mingdan; Wang, Lingman; Tian, Bing; Liu, Benke; Chen, Hengsheng; Cheng, Li; Huang, Dishu; Han, Ziyao; Yang, Xiaoyue; Liu, Jie; Jiang, Li"

作者地址："[Gui, Jianxiong; Xie, Mingdan; Wang, Lingman; Tian, Bing; Liu, Benke; Chen, Hengsheng; Cheng, Li; Huang, Dishu; Han, Ziyao; Yang, Xiaoyue; Liu, Jie; Jiang, Li] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders, Dept Neurol,Childrens Hosp,Chongqing Key Lab Child, 136 Zhongshan Er Rd, Chongqing 400014, Peoples R China; [Liu, Benke] Jinan Univ, Shenzhen Baoan Womens & Childrens Hosp, Dept Pediat, Shenzhen 518101, Peoples R China"

通信作者："Liu, J; Jiang, L (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders, Dept Neurol,Childrens Hosp,Chongqing Key Lab Child, 136 Zhongshan Er Rd, Chongqing 400014, Peoples R China."

来源：NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001178672800001

JCR分区：Q2

影响因子：3.1

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Fine particulate matter; Neurodevelopmental impairment; Synaptic plasticity; DHA; Neuroinflammation

摘要："PM2.5 exposure is a challenging environmental issue that is closely related to cognitive development impairment; however, currently, relevant means for prevention and treatment remain lacking. Herein, we determined the preventive effect of docosahexaenoic acid (DHA) supplementation on the neurodevelopmental toxicity induced by PM2.5 exposure. Neonatal rats were divided randomly into three groups: control, PM2.5, and DHA + PM2.5 groups. DHA could ameliorate PM2.5-induced learning and memory dysfunction, as well as reverse the impairment of hippocampal synaptic plasticity, evidenced by enhanced long-term potentiation, recovered synaptic ultrastructure, and increased expression of synaptic proteins. Moreover, DHA increased CREB phosphorylation and BDNF levels and attenuated neuroinflammation and oxidative stress, reflected by lower levels of IBA-1, IL-1 beta, and IL-6 and increased levels of SOD1 and Nrf2. In summary, our findings demonstrated that supplementation of DHA effectively mitigated the cognitive dysfunction and synaptic plasticity impairment induced by early postnatal exposure to PM2.5. These beneficial effects may be attributed to the upregulation of the CREB/BDNF signaling pathway, as well as the reduction of neuroinflammation and oxidative stress."

基金机构：National Natural Science Foundation of China [82301338]; China Postdoctoral Science Foundation [2022M710553]; Chongqing Postdoctoral Special Foundation [CSTB2022NSCQ-BHX0708]

基金资助正文："This work was supported by the National Natural Science Foundation of China [grant number 82301338], the China Postdoctoral Science Foundation [grant number 2022M710553], and the Chongqing Postdoctoral Special Foundation [grant number CSTB2022NSCQ-BHX0708]"