Gestational diabetes mellitus aggravates adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy

作者全名："Li, Xia; Cai, Qin-Yu; Luo, Xin; Wang, Yong-Heng; Shao, Li-Zhen; Luo, Shu-Juan; Wang, Lan; Wang, Ying-Xiong; Lan, Xia; Liu, Tai-Hang"

作者地址："[Li, Xia; Wang, Yong-Heng; Shao, Li-Zhen; Wang, Ying-Xiong; Liu, Tai-Hang] Chongqing Med Univ, Sch Basic Med Sci, Dept Bioinformat, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Li, Xia; Cai, Qin-Yu; Luo, Xin; Wang, Yong-Heng; Shao, Li-Zhen; Wang, Ying-Xiong; Liu, Tai-Hang] Chongqing Med Univ, Joint Int Res Lab Reprod & Dev, Chongqing 400016, Peoples R China; [Cai, Qin-Yu; Luo, Shu-Juan; Wang, Lan; Lan, Xia] Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet, Chongqing 401147, Peoples R China; [Luo, Xin] Chongqing Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Chongqing 400016, Peoples R China"

通信作者："Liu, TH (通讯作者)，Chongqing Med Univ, Sch Basic Med Sci, Dept Bioinformat, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.; Liu, TH (通讯作者)，Chongqing Med Univ, Joint Int Res Lab Reprod & Dev, Chongqing 400016, Peoples R China.; Lan, X (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet, Chongqing 401147, Peoples R China."

来源：DIABETOLOGY & METABOLIC SYNDROME

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001178936700002

JCR分区：Q2

影响因子：3.4

年份：2024

卷号：16

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Intrahepatic cholestasis of pregnancy; Gestational diabetes mellitus; Perinatal outcome; Bile acid; Preterm labour; Nomogram

摘要："Purpose To evaluate the effect of intrahepatic cholestasis of pregnancy (ICP) with gestational diabetes mellitus (GDM) on perinatal outcomes and establish a prediction model of adverse perinatal outcomes in women with ICP. Methods This multicenter retrospective cohort study included the clinical data of 2,178 pregnant women with ICP, including 1,788 women with ICP and 390 co-occurrence ICP and GDM. The data of all subjects were collected from hospital electronic medical records. Univariate and multivariate logistic regression analysis were used to compare the incidence of perinatal outcomes between ICP with GDM group and ICP alone group. Results Baseline characteristics of the population revealed that maternal age (p < 0.001), pregestational weight (p = 0.01), pre-pregnancy BMI (p < 0.001), gestational weight gain (p < 0.001), assisted reproductive technology (ART) (p < 0.001), and total bile acid concentration (p = 0.024) may be risk factors for ICP with GDM. Furthermore, ICP with GDM demonstrated a higher association with both polyhydramnios (OR 2.66) and preterm labor (OR 1.67) compared to ICP alone. Further subgroup analysis based on the severity of ICP showed that elevated total bile acid concentrations were closely associated with an increased risk of preterm labour, meconium-stained amniotic fluid, and low birth weight in both ICP alone and ICP with GDM groups. ICP with GDM further worsened these outcomes, especially in women with severe ICP. The nomogram prediction model effectively predicted the occurrence of preterm labour in the ICP population. Conclusions ICP with GDM may result in more adverse pregnancy outcomes, which are associated with bile acid concentrations."

基金机构：National Natural Science Foundation of China

基金资助正文：No Statement Available