Intraoperative implantation of 125I seeds improves prognosis in refractory stage IIIB cervical cancer: a case report and literature review

作者全名："Wu, Jialin; Tang, Junying; Luo, Yi; Li, Wenbo; Liu, Yingwei; Xiao, Lin"

作者地址："[Wu, Jialin; Tang, Junying; Liu, Yingwei; Xiao, Lin] Chongqing Med Univ, Affiliated Hosp 1, Dept Gynecol, Chongqing 400016, Peoples R China; [Luo, Yi] Chongqing Med Univ, Affiliated Hosp 1, Dept Oncol, Chongqing 400016, Peoples R China; [Li, Wenbo] Chongqing Med Univ, Affiliated Hosp 1, Dept Nucl Med, Chongqing 400016, Peoples R China"

通信作者："Xiao, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Gynecol, Chongqing 400016, Peoples R China."

来源：BMC WOMENS HEALTH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001179423300004

JCR分区：Q2

影响因子：2.4

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Advanced cervical cancer; Radiotherapy; 125I seeds implantation; Radical hysterectomy; Prognosis

摘要："BackgroundConcurrent chemoradiation is the standard treatment for advanced cervical cancer. However some patients still have a poor prognosis, and currently, there is no effective treatment for recurrence. In recent years, 125I seed implantation therapy has emerged as a treatment for advanced malignant tumors including surgically unresectable tumors, residual tumors after surgical resection, and metastatic tumors. However, the use of 125I seeds implantation in primary advanced cervical cancer has not been reported. In this study, we present a case of stage IIIB cervical cancer in a patient who had poor response to radiotherapy and chemotherapy. Subsequently, a radical hysterectomy was performed, and 125I radioactive seeds were successfully implanted during the surgery. This effectively controlled the lesions that were resistant to radiotherapy and had the potential to improve the prognosis.Case presentationA 56-year-old woman was diagnosed with stage IIIB (FIGO 2009) IIIC1r (FIGO 2018) squamous carcinoma of the cervix. After receiving 4 cycles of platinum-based chemotherapy and 30 rounds of radiotherapy, she underwent a radical hysterectomy. The localized cervical lesions were reduced, but there was no reduction in the size of the enlarged pelvic lymph nodes. Therefore, 125I seed implantation was performed under direct surgical vision for the right paracervical lesion and the enlarged pelvic lymph nodes on the right side. During the 18-month follow-up period, the enlarged lymph nodes subsided without any signs of recurrence or metastasis.ConclusionIntraoperative implantation of 125I seeds in lesions that are difficult to control with radiotherapy or in sites at high risk of recurrence is a feasible and effective treatment option for patients with advanced squamous cervical cancer, and it may contribute to improved survival."

基金机构："Natural Science Foundation of Chongqing, China"

基金资助正文：Not applicable.