Less common phenotypes of myelin oligodendrocyte glycoprotein antibody-related diseases in children deserve more attention

作者全名："Wang, Xiao-yu; Jiang, Yan; Wu, Peng; Ma, Jian-nan; Yuan, Ping; Li, Xiu-juan; Jiang, Li"

作者地址："[Wang, Xiao-yu; Jiang, Yan; Wu, Peng; Ma, Jian-nan; Yuan, Ping; Li, Xiu-juan; Jiang, Li] Chongqing Med Univ, Chongqing Key Lab child Neurodev & Cognit Disorder, Key Lab Child Dev & Disorder, Dept Neurol,Childrens Hosp,Minist Educ, Chongqing, Peoples R China; [Wang, Xiao-yu; Jiang, Yan; Wu, Peng; Ma, Jian-nan; Yuan, Ping; Li, Xiu-juan; Jiang, Li] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp, Chongqing, Peoples R China; [Wang, Xiao-yu; Jiang, Yan; Wu, Peng; Ma, Jian-nan; Yuan, Ping; Li, Xiu-juan; Jiang, Li] Chongqing Med Univ, China Int Sci & Technol Cooperat base Child Dev &, Childrens Hosp, Chongqing, Peoples R China"

通信作者："Yuan, P; Li, XJ (通讯作者)，Chongqing Med Univ, Chongqing Key Lab child Neurodev & Cognit Disorder, Key Lab Child Dev & Disorder, Dept Neurol,Childrens Hosp,Minist Educ, Chongqing, Peoples R China.; Yuan, P; Li, XJ (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp, Chongqing, Peoples R China.; Yuan, P; Li, XJ (通讯作者)，Chongqing Med Univ, China Int Sci & Technol Cooperat base Child Dev &, Childrens Hosp, Chongqing, Peoples R China."

来源：PEDIATRIC RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001179632900003

JCR分区：Q1

影响因子：3.1

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：　

摘要："BackgroundTo facilitate the identification of less common clinical phenotypes of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) in children.MethodsWe retrospectively reviewed medical records of 236 patients with MOGAD. The following phenotypes were considered to be typical for MOGAD: ADEM, ON, TM, and NMOSD. Less common onset clinical phenotypes were screened out; their clinical and magnetic resonance imaging (MRI), diagnosis, treatment, and prognosis were summarized and analyzed.Results16 cases (6.8%) presented as cortical encephalitis, with convulsions, headache, and fever as the main symptoms. 15 cases were misdiagnosed in the early period. 13 cases (5.5%) showed the overlapping syndrome of MOGAD and anti-N-methyl-D aspartate receptor encephalitis (MNOS), with seizures (92.3%) being the most common clinical symptom. 11 cases (84.6%) showed relapses. The cerebral leukodystrophy-like phenotype was present in seven cases (3.0%), with a recurrence rate of 50%. Isolated seizures without any findings on MRI phenotype was present in three cases (1.3%), with the only clinical symptom being seizures of focal origin. Three cases (1.3%) of aseptic meningitis phenotype presented with prolonged fever.Conclusion40/236 (16.9%) of children with MOGAD had less common phenotypes. Less common clinical phenotypes of pediatric MOGAD are susceptible to misdiagnosis and deserve more attention.ImpactThis is the first comprehensive analysis and summary of all less commonl clinical phenotypes of MOGAD in children, while previous studies have only focused on a specific phenotype or case reports.We analyzed the characteristics of MOGAD in children and further revealed the reasons why these less common clinical phenotypes are prone to misdiagnosis and deserve more attention.Our research on treatment has shown that early detection of MOG antibodies and early treatment are of great significance for improving the prognosis of these patients."

基金机构：CQMU Program for Yourth Inovation in Future Medicine [W0116]; National Natural Science Foundation of China (NSFC) [82001391]; Natural Science Foundation of Chongqing [2020]117-cstc2020jcyj-msxmX0388]

基金资助正文："This research was supported by the CQMU Program for Yourth Inovation in Future Medicine (W0116), the National Natural Science Foundation of China (NSFC Grant numbers 82001391) and the Natural Science Foundation of Chongqing (Grantnumber: [2020]117-cstc2020jcyj-msxmX0388)."