Effect of soy isoflavone supplementation on blood pressure: a meta-analysis of randomized controlled trials

作者全名："Lei, Lifu; Hui, Suocheng; Chen, Yushi; Yan, Hongjia; Yang, Jian; Tong, Shiwen"

作者地址："[Lei, Lifu; Chen, Yushi; Tong, Shiwen] Chongqing Med Univ, Dept Clin Nutr, Affiliated Hosp 2, Chongqing 400016, Peoples R China; [Hui, Suocheng; Yan, Hongjia] Peoples Hosp Chongqing Liang Jiang New Area, Dept Clin Nutr, Chongqing 401135, Peoples R China; [Yang, Jian] Chongqing Med Univ, Dept Clin Nutr, Affiliated Hosp 3, Chongqing 410020, Peoples R China; [Yang, Jian] Chongqing Med Univ, Res Ctr Metab & Cardiovasc Dis, Affiliated Hosp 3, Chongqing 410020, Peoples R China"

通信作者："Tong, SW (通讯作者)，Chongqing Med Univ, Dept Clin Nutr, Affiliated Hosp 2, Chongqing 400016, Peoples R China.; Yang, J (通讯作者)，Chongqing Med Univ, Dept Clin Nutr, Affiliated Hosp 3, Chongqing 410020, Peoples R China.; Yang, J (通讯作者)，Chongqing Med Univ, Res Ctr Metab & Cardiovasc Dis, Affiliated Hosp 3, Chongqing 410020, Peoples R China."

来源：NUTRITION JOURNAL

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001180555800001

JCR分区：Q1

影响因子：4.4

年份：2024

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Soy isoflavone; Systolic blood pressure; Diastolic blood pressure; Hypertension; Dose-response

摘要："BackgroundPrevious experimental studies have suggested that the consumption of soy isoflavones may have a potential impact on lowering blood pressure. Nevertheless, epidemiological studies have presented conflicting outcomes concerning the correlation between soy isoflavone consumption and blood pressure levels. Consequently, a comprehensive meta-analysis of all eligible randomized controlled trials (RCTs) was conducted to explore the influence of soy isoflavones on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in adults.MethodsA thorough search of PubMed, Embase, and the Cochrane Library for relevant literature up to April 30, 2023 was conducted. RCTs involving adults that compared soy isoflavone supplementation with a placebo (the same matrix devoid of soy isoflavone) were included. The combined effect size was presented as the weighted mean difference (WMD) along with 95% confidence interval (CI), employing a fixed-effects model.ResultsOur meta-analysis included a total of 24 studies involving 1945 participants. The results revealed a significant reduction in both SBP and DBP with soy isoflavone supplementation. Subgroup analyses suggested more pronounced reductions in SBP and DBP for interventions lasting >= 6 months, in individuals receiving mixed-type soy isoflavone, and among patients with metabolic syndrome or prehypertension. However, we did not detect significant nonlinear associations between supplementation dosage and intervention duration concerning both SBP and DBP. The overall quality of evidence was deemed moderate.ConclusionsThe current meta-analysis revealed that supplementation with soy isoflavones alone effectively reduces blood pressure. Additional high-quality studies are required to investigate the efficacy of blood pressure reduction through supplementation with an optimal quantity and proportion of soy isoflavone."

基金机构：China Postdoctoral Science Foundation

基金资助正文：Not applicable.