Association of domain-specific physical activity with albuminuria among prediabetes and diabetes: a large cross-sectional study

作者全名："Xiong, Bingquan; Wang, Yufan; He, Juan; Wang, Lisha; He, Rui; Zhu, Min; Wang, Jiaxing; Li, Yingrui; Liu, Bin; Xiao, Kaihu; She, Qiang"

作者地址："[Xiong, Bingquan; He, Juan; Wang, Lisha; Li, Yingrui; Liu, Bin; Xiao, Kaihu; She, Qiang] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China; [Wang, Yufan] Hainan Med Univ, Dept Cardiovasc Med Intens Care Unit, Affiliated Hosp 2, Hainan, Peoples R China; [He, Rui] Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China; [Zhu, Min] First Peoples Hosp Neijiang, Dept Geriatr, 41 Tuozhong Lane,Jiaotong Rd, Neijiang 641000, Sichuan, Peoples R China; [Wang, Jiaxing] Jinan Univ, Dept Endocrinol & Metab, Affiliated Hosp 1, 613 Huang Pu Ave West, Guangzhou, Guangdong, Peoples R China"

通信作者："She, Q (通讯作者)，Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：JOURNAL OF TRANSLATIONAL MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001181400100002

JCR分区：Q1

影响因子：6.1

年份：2024

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Physical activity; Diabetes; Albuminuria; Risk; Lifestyle

摘要："Background Albuminuria, the presence of excess of protein in urine, is a well-known risk factor for early kidney damage among diabetic/prediabetic patients. There is a complex interaction between physical activity (PA) and albuminuria. However, the relationship of specific-domain PA and albuminuria remained obscure. Methods Albuminuria was defined as urinary albumin/creatinine ratio (ACR) > 30 mg/g. PA was self-reported by participants and classified into transportation-related PA (TPA), occupation-related PA (OPA), and leisure-time PA (LTPA). Weighted logistic regression was conducted to compute the odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic spline (RCS) was used to evaluate the dose-response of PA domains with the risk of albuminuria. Results A total of 6739 diabetic/prediabetic patients (mean age: 56.52 +/- 0.29 years) were enrolled in our study, including 3181 (47.20%) females and 3558 (52.80%) males. Of them, 1578 (23.42%) were identified with albuminuria, and 5161(76.58%) were without albuminuria. Diabetic/prediabetic patients who adhered the PA guidelines for total PA had a 22% decreased risk of albuminuria (OR = 0.78, 95%CI 0.64-0.95), and those met the PA guidelines for LTPA had a 28% decreased of albuminuria (OR = 0.72, 95%CI 0.57-0.92). However, OPA and TPA were both not associated with decreased risk of albuminuria. RCS showed linear relationship between the risk of albuminuria with LTPA. Conclusions Meeting the PA guideline for LTPA, but not OPA and TPA, was inversely related to the risk of albuminuria among diabetic/prediabetic patients. Additionally, achieving more than 300 min/week of LTPA conferred the positive effects in reducing albuminuria among diabetic/prediabetic patients."

基金机构：Key Project of Technology Innovation and Application Development in Chongqing [CSTB2023TIAD-KPX0048]; Construction of graduate tutor team in Chongqing Medical University [cqmudstd202205]

基金资助正文："This work was supported by the Key Project of Technology Innovation and Application Development in Chongqing (CSTB2023TIAD-KPX0048), and Construction of graduate tutor team in Chongqing Medical University (cqmudstd202205)."