Impact of body composition on the prognosis of hepatocellular carcinoma patients treated with transarterial chemoembolization: A systematic review and meta-analysis
作者全名："Wang, Anrong; Li, Junfeng; Li, Changfeng; Zhang, Hui; Fan, Yingfang; Ma, Kuansheng; Wang, Qiang"
作者地址："[Wang, Anrong] Chongqing Med Univ, Affiliated Hosp 1, Dept Vasc Surg, Chongqing, Peoples R China; [Wang, Anrong] Peoples Hosp Dianjiang Cty, Dept Intervent Therapy, Chongqing, Peoples R China; [Li, Junfeng] Peoples Hosp Dianjiang Cty, Dept Oncol, Chongqing, Peoples R China; [Li, Changfeng; Zhang, Hui; Ma, Kuansheng] Army Med Univ, Southwest Hosp, Inst Hepatobiliary Surg, Chongqing, Peoples R China; [Fan, Yingfang] Southern Med Univ, Affiliated Hosp 3, Dept Hepatobiliary Surg, Guangzhou, Peoples R China; [Wang, Qiang] Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Div Med Imaging & Technol, Stockholm, Sweden; [Wang, Qiang] Karolinska Univ Hosp Huddinge, Dept Radiol, Stockholm, Sweden; [Wang, Qiang] Room 601, Novum PI 6, Hiss, Halsovagen 7, SE-14186 Huddinge, Sweden"
通信作者："Wang, Q (通讯作者)，Room 601, Novum PI 6, Hiss, Halsovagen 7, SE-14186 Huddinge, Sweden."
来源：HELIYON
ESI学科分类：
WOS号：WOS:001181712700001
JCR分区：Q1
影响因子：3.4
年份：2024
卷号：10
期号：3
开始页：
结束页：
文献类型：Article
关键词：Body composition; Sarcopenia; Transarterial chemoembolization; Hepatocellular carcinoma; Meta -analysis
摘要："Objectives: To summarize current evidence about the influence of body composition on the prognosis of patients with hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE) treatment. Methods: Public databases were systematically searched to identify relevant studies published from the inception of the database up to May 2023. Studies that evaluated the association between body composition and clinical outcomes in HCC patients who underwent TACE were included. A pre -designed table was applied to summarize relevant information. Meta -analysis was performed to estimate the association of body composition with overall survival. Results: Fourteen studies were included in this review, including 3631 patients (sample size range: 56-908, median 186). All body composition measurements (including skeletal muscle area, visceral and subcutaneous adipose area, and bone mineral density) were based on computer tomography. The commonly used parameter was skeletal muscle index at 3rd lumbar vertebra level (8/14). Three studies evaluated the correlations of body composition changes with the prognosis after TACE. Most studies (12/14) identified body composition parameters as an independent indicator for overall survival, progression -free survival, and treatment response rate. The hazard ratio of different body composition parameters ranged from 1.01 to 2.88, and hazard ratio of body composition changes ranged from 1.88 to 5.93. The pooled hazard ratio of sarcopenia for overall survival was 1.38 (95 %CI: 1.20-1.58). Conclusions: Body composition seems to be an important prognostic factor for a poorer clinical outcome after TACE treatment in patients with hepatocellular carcinoma. Future prospective studies with a larger sample size are required to confirm these findings."
基金机构：Karolinska Institutet Erik and Edith Fernstrom Foundation [2023-00979]; Ruth and Richard Julin Foundation [2023-00474]
基金资助正文："This work was funded by Karolinska Institutet Erik and Edith Fernstrom Foundation (No. 2023-00979) and Ruth and Richard Julin Foundation (No.2023-00474) . The funders did not involve in the study design, and collection, analysis, and interpretation of data and in writing the manuscript."
