Interaction Between Microbubbles and Microwave Ablation

作者全名："Zhong, Xinyu; Zhang, Xinghao; Cao, Yuting; Zhou, Ping"

作者地址："[Zhong, Xinyu; Zhang, Xinghao; Zhou, Ping] Cent South Univ, Xiangya Hosp 3, Dept Ultrasound, Changsha, Peoples R China; [Cao, Yuting] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing, Peoples R China; [Cao, Yuting] Chongqing Med Univ, Affiliated Hosp 2, Dept Ultrasound, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing, Peoples R China; [Zhou, Ping] Cent South Univ, Xiangya Hosp 3, Dept Ultrasound, Changsha 410013, Hunan, Peoples R China"

通信作者："Zhou, P (通讯作者)，Cent South Univ, Xiangya Hosp 3, Dept Ultrasound, Changsha 410013, Hunan, Peoples R China."

来源：JOURNAL OF ULTRASOUND IN MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001182337100001

JCR分区：Q2

影响因子：2.1

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：contrast-enhanced ultrasound; imaging monitoring; microbubbles; microwave ablation; phantoms; ultrasound

摘要："ObjectivesThis study aimed to explore the interactions between microbubbles and microwave ablation (MWA).MethodsThe study employed custom-made phantoms (in vitro) and white New Zealand rabbits (in vivo). MWA was performed with or without microbubbles in the phantoms (2 x 105 particles mL-1) and rabbit livers (intravenous injection of 0.05 mL/kg SonoVue). During the MWA, K-type thermocouple probes were used to monitor the MWA-induced temperature increase. Contrast-enhanced ultrasound imaging (CEUS) was used to monitor and analyze the microbubbles signal intensity. After MWA, the ablation-zone volumes were evaluated and compared between the groups with and without microbubbles.ResultsIn both the phantom models and rabbits, microbubbles showed no significant influence on MWA, including the ablation range and MWA-induced temperature increase. In phantoms and rabbit livers filled with microbubbles, MWA caused the formation of a gradually expanding microbubble-defect region over the ablation time. An increase in the temperature caused microbubble destruction.ConclusionsMicrobubbles had no significant influence on MWA. However, MWA induced the destruction of microbubbles in a temperature-dependent manner. Thus, the poor thermotolerance of microbubbles is a non-negligible barrier when using CEUS to monitor the ablation range during MWA in real-time."

基金机构：National Natural Science Foundation of China

基金资助正文：No Statement Available